Glypican 5 Explained

Glypican-5 is a protein that in humans is encoded by the GPC5 gene.^{[1] [2]}

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.^[3]

See also

• Glypican

Further reading

• De Cat B, David G . Developmental roles of the glypicans. . Semin. Cell Dev. Biol. . 12 . 2 . 117–25 . 2001 . 11292377 . 10.1006/scdb.2000.0240 .
• Watanabe K, Yamada H, Yamaguchi Y . K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney. . J. Cell Biol. . 130 . 5 . 1207–18 . 1995 . 7657705 . 10.1083/jcb.130.5.1207 . 2120559 .
• Saunders S, Paine-Saunders S, Lander AD . Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain. . Dev. Biol. . 190 . 1 . 78–93 . 1997 . 9331333 . 10.1006/dbio.1997.8690 . 25320509 .
• Veugelers M, De Cat B, Delande N, etal . A 4-Mb BAC/PAC contig and complete genomic structure of the GPC5/GPC6 gene cluster on chromosome 13q32. . Matrix Biol. . 20 . 5–6 . 375–85 . 2002 . 11566272 . 10.1016/S0945-053X(01)00143-3 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Yu W, Inoue J, Imoto I, etal . GPC5 is a possible target for the 13q31-q32 amplification detected in lymphoma cell lines . J. Hum. Genet. . 48 . 6 . 331–5 . 2004 . 12721791 . 10.1007/s10038-003-0026-2 . free .
• Dunham A, Matthews LH, Burton J, etal . The DNA sequence and analysis of human chromosome 13 . Nature . 428 . 6982 . 522–8 . 2004 . 15057823 . 10.1038/nature02379 . 2665288 . 2004Natur.428..522D .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .

Notes and References

1. Veugelers M, Vermeesch J, Reekmans G, Steinfeld R, Marynen P, David G . Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family . Genomics . 40 . 1 . 24–30 . Jun 1997 . 9070915 . 10.1006/geno.1996.4518 .
2. Web site: Entrez Gene: GPC5 glypican 5.
3. Web site: Entrez Gene: GPC5 glypican 5.