Glycylpeptide N-tetradecanoyltransferase 2 explained

Glycylpeptide N-tetradecanoyltransferase 2 known also as N-myristoyltransferase, is an enzyme (EC: 2.3.1.97) that in humans is encoded by the NMT2 gene.^[1]

Function

N-myristoyltransferase (NMT) catalyzes the reaction of N-terminal myristoylation of many signaling proteins. It transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue. Biochemical evidence indicates the presence of several distinct NMTs, varying in apparent molecular weight and /or subcellular distribution. The 496-amino acid of human NMT2 protein shares 77% and 96% sequence identity with human NMT1 and mouse Nmt2 comprise two distinct families of N-myristoyltransferases.^[2]

Interactions

NMT2 has been shown to interact with:

• caspase 3^[3]
• MARCKS^[4]

See also

• N-myristoyltransferase 1

Further reading

• Kolluri SK, Balduf C, Hofmann M, Göttlicher M . Novel target genes of the Ah (dioxin) receptor: transcriptional induction of N-myristoyltransferase 2 . Cancer Res. . 61 . 23 . 8534–9 . 2002 . 11731439 .
• Wright MH, Clough B, Rackham MD, Rangachari K, Brannigan JA, Grainger M, Moss DK, Bottrill AR, Heal WP, Broncel M, Serwa RA, Brady D, Mann DJ, Leatherbarrow RJ, Tewari R, Wilkinson AJ, Holder AA, Tate EW . Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach. . Nat Chem . 6 . 2 . 112–21 . 2014 . 24451586 . 10.1038/nchem.1830 . 4739506. 2014NatCh...6..112W .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Glycylpeptide N-tetradecanoyltransferase 2 (NMT2)

Notes and References

1. Giang DK, Cravatt BF . A second mammalian N-myristoyltransferase . J Biol Chem . 273 . 12 . 6595–8 . Apr 1998 . 9506952 . 10.1074/jbc.273.12.6595 . free .
2. Thinon E, Serwa RA, Broncel M, Brannigan JA, Brassat U, Wright MH, Heal WP, Wilkinson AJ, Mann DJ, Tate EW . Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. . Nat Commun . 5 . 4919 . 2014 . 25255805 . 10.1038/ncomms5919 . 4200515. 2014NatCo...5.4919T .
3. Selvakumar P, Sharma RK . Role of calpain and caspase system in the regulation of N-myristoyltransferase in human colon cancer (Review). . Int J Mol Med . 19 . 5 . 823–7 . 2007 . 17390089 . 10.3892/ijmm.19.5.823. free .
4. Selvakumar P, Lakshmikuttyamma A, Sharma RK . Biochemical characterization of bovine brain myristoyl-CoA:protein N-myristoyltransferase type 2. . J Biomed Biotechnol . 2009 . 907614 . 2009 . 19746168 . 10.1155/2009/907614 . 2737134. free .