Glycosylceramidase Explained

Glycosylceramidase
Ec Number:	3.2.1.62
Cas Number:	9033-10-7
Go Code:	0017042

The enzyme glycosylceramidase catalyzes the following chemical reaction:

glycosyl-N-acylsphingosine + H₂O

\rightleftharpoons N-acylsphingosine + a sugar

It belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is glycosyl-N-acylsphingosine glycohydrolase. Other names in common use include phlorizin hydrolase, phloretin-glucosidase, glycosyl ceramide glycosylhydrolase, cerebrosidase, phloridzin β-glucosidase, lactase-phlorizin hydrolase, and phloridzin glucosidase.

References

• Leese HJ, Semenza G . 1973 . On the identity between the small intestinal enzymes phlorizin hydrolase and glycosylceramidase . J. Biol. Chem. . 248 . 8170 - 3 . 4752949 . 23 .
• Lorenz-Meyer H, Blum AL, Haemmerli HP, Semenza G . 1972 . A second enzyme defect in acquired lactase deficiency: lack of small-intestinal phlorizin-hydrolase . Eur. J. Clin. Invest. . 2 . 326 - 31 . 5082068 . 10.1111/j.1365-2362.1972.tb00658.x . 5 .
• Malathi P, Crane RK . 1969 . Phlorizin hydrolase: a β-glucosidase of hamster intestinal brush border membrane . Biochim. Biophys. Acta . 173 . 245 - 56 . 5774775 . 2 . 10.1016/0005-2736(69)90108-4.