Glycoside hydrolase family 97 explained

Symbol:Glyco_hydro_97
Glycoside hydrolase 97
Pfam:PF10566
Pfam Clan:CL0058
Interpro:IPR019563

In molecular biology, glycoside hydrolase family 97 is a family of glycoside hydrolases.

Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[1] [2] [3] This classification is available on the CAZy web site,[4] [5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[6] [7]

Glycoside hydrolase family 97 (GH97) is a bacterial family. The central part of the GH97 family protein sequences represents a typical and complete (beta/alpha)8-barrel or catalytic TIM-barrel type domain. The N- and C-terminal parts of the sequences, mainly consisting of beta-strands, most probably form two additional non-catalytic domains with as yet unknown functions. The non-catalytic domains of glycosidases from the alpha-galactosidase and alpha-glucosidase superfamilies are also predominantly composed of beta-strands, and at least some of these domains are involved in oligomerisation and carbohydrate binding. In all known glycosidases with the (beta-alpha)8-barrel fold, the amino acid residues at the active site are located on the C-termini of the beta-strands.[8]

External links

Notes and References

  1. Henrissat B, Callebaut I, Mornon JP, Fabrega S, Lehn P, Davies G . Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases . Proc. Natl. Acad. Sci. U.S.A. . 92 . 15 . 7090–7094 . 1995 . 7624375 . 10.1073/pnas.92.15.7090 . 41477. 1995PNAS...92.7090H . free .
  2. Henrissat B, Davies G . Structures and mechanisms of glycosyl hydrolases . Structure . 3 . 9 . 853–859 . 1995 . 8535779 . 10.1016/S0969-2126(01)00220-9. free .
  3. Web site: Bairoch, A. "Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT". 1999. . 2011-10-04 . 2011-05-25 . https://web.archive.org/web/20110525140109/http://www.expasy.ch/cgi-bin/lists?glycosid.txt . dead .
  4. Web site: Home. CAZy.org. en. 2018-03-06.
  5. Lombard. Vincent. Golaconda Ramulu. Hemalatha. Drula. Elodie. Coutinho. Pedro M.. Henrissat. Bernard. 2014-01-01. The carbohydrate-active enzymes database (CAZy) in 2013. Nucleic Acids Research. en. 42. D1. D490–D495. 10.1093/nar/gkt1178. 24270786. 3965031. 0305-1048.
  6. Web site: Glycoside Hydrolase Family 97. CAZypedia.org. en. 2018-03-06.
  7. CAZypedia Consortium. 2018-12-01. Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes. Glycobiology. 28. 1. 3–8. 10.1093/glycob/cwx089. 1460-2423. 29040563. 21.11116/0000-0003-B7EB-6. free. free.
  8. Naumoff DG . GH97 is a new family of glycoside hydrolases, which is related to the alpha-galactosidase superfamily . BMC Genomics . 6 . 112 . 2005 . 16131397 . 1249566 . 10.1186/1471-2164-6-112 . free .

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