Glycoside hydrolase family 9 explained

Symbol:	Glyco_hydro_9
Glycosyl hydrolase family 9
Pfam:	PF00759
Pfam Clan:	CL0059
Prosite:	PDOC00511
Scop:	1clc
Cazy:	GH9
Membranome Family:	1017

In molecular biology, glycoside hydrolase family 9 is a family of glycoside hydrolases.

Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.^{[1] [2] [3]} This classification is available on the CAZy web site,^{[4] [5]} and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.^{[6] [7]}

Glycoside hydrolase family 9 CAZY GH_9 comprises enzymes with several known activities including endoglucanase and cellobiohydrolase . These enzymes were formerly known as cellulase family E. Cellulases (Endoglucanases) catalyse the endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose. GH9 family members have also been found in green microalgae (Chlamydomonas, Gonium and Volvox) that show highest sequence identity to endogenous GH9 cellulases from invertebrate metazoans ^{[8] [9]}

Notes and References

1. Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G . Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases . Proceedings of the National Academy of Sciences of the United States of America . 92 . 15 . 7090–4 . July 1995 . 7624375 . 41477 . 10.1073/pnas.92.15.7090 . 1995PNAS...92.7090H . free .
2. Davies G, Henrissat B . Structures and mechanisms of glycosyl hydrolases . Structure . 3 . 9 . 853–9 . September 1995 . 8535779 . 10.1016/S0969-2126(01)00220-9 . free .
3. Henrissat B, Bairoch A . Updating the sequence-based classification of glycosyl hydrolases . The Biochemical Journal . 316 . Pt 2 . 695–6 . June 1996 . 8687420 . 1217404 . 10.1042/bj3160695.
4. Web site: Home. CAZy.org. en. 2018-03-06.
5. Lombard V, Golaconda Ramulu H, Drula E, Coutinho PM, Henrissat B . The carbohydrate-active enzymes database (CAZy) in 2013 . Nucleic Acids Research . 42 . Database issue . D490-5 . January 2014 . 24270786 . 3965031 . 10.1093/nar/gkt1178 .
6. Web site: Glycoside Hydrolase Family 9. CAZypedia.org. en. 2018-03-06.
7. Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes . Glycobiology . 28 . 1 . 3–8 . December 2018 . 29040563 . 10.1093/glycob/cwx089 . CAZypedia Consortium . free . 21.11116/0000-0003-B7EB-6 . free .
8. Guerriero G. Sergeant K. Legay S. Hausman J.-F. Cauchie H.-M. Ahmad I. Siddiqui K.S . Int. J. Mol. Sci. 2018, 19, 1782
9. Web site: Prosite .