Glycoside hydrolase family 77 explained

Symbol:	Glyco_hydro_77
Glyco_hydro_77
Pfam:	PF02446
Pfam Clan:	CL0058
Interpro:	IPR003385
Scop:	1cwy
Cazy:	GH77

In molecular biology, glycoside hydrolase family 77 is a family of glycoside hydrolases.

Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.^{[1] [2] [3]} This classification is available on the CAZy web site,^{[4] [5]} and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.^{[6] [7]}

The enzymes in this family have amylomaltase or 4-α-glucanotransferase activity CAZY GH_77, they transfer a segment of a (1,4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1,4)-alpha-D-glucan.^[8] They belong to the disproportionating family of enzymes.

Notes and References

1. Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G. July 1995. Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases. Proceedings of the National Academy of Sciences of the United States of America. 92. 15. 7090–4. 10.1073/pnas.92.15.7090. 41477. 7624375. 1995PNAS...92.7090H. free.
2. Davies G, Henrissat B. September 1995. Structures and mechanisms of glycosyl hydrolases. Structure. 3. 9. 853–9. 10.1016/S0969-2126(01)00220-9. 8535779. free.
3. Henrissat B, Bairoch A. June 1996. Updating the sequence-based classification of glycosyl hydrolases. The Biochemical Journal. 316. Pt 2. 695–6. 1217404. 8687420. 10.1042/bj3160695.
4. Web site: Home. CAZy.org. en. 2018-03-06.
5. Lombard V, Golaconda Ramulu H, Drula E, Coutinho PM, Henrissat B. January 2014. The carbohydrate-active enzymes database (CAZy) in 2013. Nucleic Acids Research. 42. Database issue. D490–5. 10.1093/nar/gkt1178. 24270786. 3965031.
6. Web site: Glycoside Hydrolase Family 77. CAZypedia.org. en. 2018-03-06.
7. December 2018. Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes. Glycobiology. 28. 1. 3–8. 10.1093/glycob/cwx089. 29040563. CAZypedia Consortium. free.
8. Okada S, Takaha T, Yanase M, Smith SM . Disproportionating enzyme (4-alpha-glucanotransferase; EC 2.4.1.25) of potato. Purification, molecular cloning, and potential role in starch metabolism . J. Biol. Chem. . 268 . 2 . 1391–1396 . 1993 . 10.1016/S0021-9258(18)54088-6 . 7678257. free .