Glycoside hydrolase family 63 explained

Symbol:	Glyco_hydro_63
Mannosyl oligosaccharide glucosidase
Pfam:	PF03200
Pfam Clan:	CL0059
Interpro:	IPR004888
Cazy:	GH63
Membranome Family:	527

In molecular biology, glycoside hydrolase family 63 is a family of glycoside hydrolases.

Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.^{[1] [2] [3]} This classification is available on the CAZy web site,^{[4] [5]} and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.^{[6] [7]}

Glycosyl hydrolase family 63 (CAZY GH_63) is a family of eukaryotic enzymes. They catalyse the specific cleavage of the non-reducing terminal glucose residue from Glc(3)Man(9)GlcNAc(2). Mannosyl oligosaccharide glucosidase is the first enzyme in the N-linked oligosaccharide processing pathway.

Notes and References

1. Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G. July 1995. Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases. Proceedings of the National Academy of Sciences of the United States of America. 92. 15. 7090–4. 10.1073/pnas.92.15.7090. 41477. 7624375. 1995PNAS...92.7090H. free.
2. Davies G, Henrissat B. September 1995. Structures and mechanisms of glycosyl hydrolases. Structure. 3. 9. 853–9. 10.1016/S0969-2126(01)00220-9. 8535779. free.
3. Henrissat B, Bairoch A. June 1996. Updating the sequence-based classification of glycosyl hydrolases. The Biochemical Journal. 316. Pt 2. 695–6. 1217404. 8687420. 10.1042/bj3160695.
4. Web site: Home. CAZy.org. en. 2018-03-06.
5. Lombard V, Golaconda Ramulu H, Drula E, Coutinho PM, Henrissat B. January 2014. The carbohydrate-active enzymes database (CAZy) in 2013. Nucleic Acids Research. 42. Database issue. D490–5. 10.1093/nar/gkt1178. 24270786. 3965031.
6. Web site: Glycoside Hydrolase Family 63. CAZypedia.org. en. 2018-03-06.
7. December 2018. Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes. Glycobiology. 28. 1. 3–8. 10.1093/glycob/cwx089. 29040563. CAZypedia Consortium. free.