Glycoside hydrolase family 52 explained

Symbol:	Glyco_hydro_52
Glyco_hydro_52
Pfam:	PF03512
Interpro:	IPR000852
Cazy:	GH52

In molecular biology, glycoside hydrolase family 52 is a family of glycoside hydrolases.

Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.^{[1] [2] [3]} This classification is available on the CAZy web site,^{[4] [5]} and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.^{[6] [7]}

Glycoside hydrolase family 52 CAZY GH_52 comprises enzymes with only one known activity; beta-xylosidase .

Proteins harboring beta-xylosidase and xylanase activities ^[8] have been identified in the Gram-positive, facultative thermophilic aerobe Bacillus stearothermophilus 21.^[8] This microbe, which functions in xylan degradation, can utilise xylan as a sole source of carbon. The enzyme hydrolyses 1,4-beta-D-xylans, removing successive D-xylose residues from the non-reducing termini. It also hydrolyses xylobiose.

Notes and References

1. Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G. July 1995. Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases. Proceedings of the National Academy of Sciences of the United States of America. 92. 15. 7090–4. 10.1073/pnas.92.15.7090. 41477. 7624375. 1995PNAS...92.7090H. free.
2. Davies G, Henrissat B. September 1995. Structures and mechanisms of glycosyl hydrolases. Structure. 3. 9. 853–9. 10.1016/S0969-2126(01)00220-9. 8535779. free.
3. Henrissat B, Bairoch A. June 1996. Updating the sequence-based classification of glycosyl hydrolases. The Biochemical Journal. 316 (Pt 2). Pt 2. 695–6. 1217404. 8687420. 10.1042/bj3160695.
4. Web site: Home. CAZy.org. en. 2018-03-06.
5. Lombard V, Golaconda Ramulu H, Drula E, Coutinho PM, Henrissat B. January 2014. The carbohydrate-active enzymes database (CAZy) in 2013. Nucleic Acids Research. 42. Database issue. D490-5. 10.1093/nar/gkt1178. 24270786. 3965031.
6. Web site: Glycoside Hydrolase Family 52. CAZypedia.org. en. 2018-03-06.
7. December 2018. Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes. Glycobiology. 28. 1. 3–8. 10.1093/glycob/cwx089. 29040563. CAZypedia Consortium. 21.11116/0000-0003-B7EB-6. free.
8. Baba T, Shinke R, Nanmori T . Identification and characterization of clustered genes for thermostable xylan-degrading enzymes, beta-xylosidase and xylanase, of Bacillus stearothermophilus 21 . Appl. Environ. Microbiol. . 60 . 7 . 2252–8 . July 1994 . 8074507 . 201640 . 10.1128/AEM.60.7.2252-2258.1994. 1994ApEnM..60.2252B .