Glycoside hydrolase family 31 explained

Symbol:Glyco_hydro_31
Glycosyl hydrolases family 31
Pfam:PF01055
Pfam Clan:CL0058
Interpro:IPR000322
Prosite:PDOC00120
Cazy:GH31
Membranome Family:523

In molecular biology, glycoside hydrolase family 31 is a family of glycoside hydrolases.

Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[1] [2] [3] This classification is available on the CAZy web site,[4] [5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[6] [7]

Glycoside hydrolase family 31 CAZY GH_31 comprises enzymes with several known activities; alpha-glucosidase, alpha-galactosidase ; glucoamylase, sucrase-isomaltase ; alpha-xylosidase ; alpha-glucan lyase .

Glycoside hydrolase family 31 groups a number of glycosyl hydrolases on the basis of sequence similarities[8] [9] [10] An aspartic acid has been implicated[11] in the catalytic activity of sucrase, isomaltase, and lysosomal alpha-glucosidase.

External links

Notes and References

  1. Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G . Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases . Proceedings of the National Academy of Sciences of the United States of America . 92 . 15 . 7090–4 . July 1995 . 7624375 . 41477 . 10.1073/pnas.92.15.7090 . 1995PNAS...92.7090H . free .
  2. Davies G, Henrissat B . Structures and mechanisms of glycosyl hydrolases . Structure . 3 . 9 . 853–9 . September 1995 . 8535779 . 10.1016/S0969-2126(01)00220-9 . free .
  3. Henrissat B, Bairoch A . Updating the sequence-based classification of glycosyl hydrolases . The Biochemical Journal . 316 . Pt 2 . 695–6 . June 1996 . 8687420 . 1217404 . 10.1042/bj3160695.
  4. Web site: Home. CAZy.org. en. 2018-03-06.
  5. Lombard V, Golaconda Ramulu H, Drula E, Coutinho PM, Henrissat B . The carbohydrate-active enzymes database (CAZy) in 2013 . Nucleic Acids Research . 42 . Database issue . D490-5 . January 2014 . 24270786 . 10.1093/nar/gkt1178 . 3965031 .
  6. Web site: Glycoside Hydrolase Family 31. CAZypedia.org. en. 2018-03-06.
  7. Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes . Glycobiology . 28 . 1 . 3–8 . December 2018 . 29040563 . 10.1093/glycob/cwx089 . CAZypedia Consortium . free .
  8. Henrissat B . A classification of glycosyl hydrolases based on amino acid sequence similarities . The Biochemical Journal . 280 . 2 . 309–16 . December 1991 . 1747104 . 1130547 . 10.1042/bj2800309 .
  9. Kinsella BT, Hogan S, Larkin A, Cantwell BA . Primary structure and processing of the Candida tsukubaensis alpha-glucosidase. Homology with the rabbit intestinal sucrase-isomaltase complex and human lysosomal alpha-glucosidase . European Journal of Biochemistry . 202 . 2 . 657–64 . December 1991 . 1761061 . 10.1111/j.1432-1033.1991.tb16420.x . free .
  10. Naim HY, Niermann T, Kleinhans U, Hollenberg CP, Strasser AW . Striking structural and functional similarities suggest that intestinal sucrase-isomaltase, human lysosomal alpha-glucosidase and Schwanniomyces occidentalis glucoamylase are derived from a common ancestral gene . FEBS Letters . 294 . 1–2 . 109–12 . December 1991 . 1743281 . 10.1016/0014-5793(91)81353-A . 6086792 .
  11. Hermans MM, Kroos MA, van Beeumen J, Oostra BA, Reuser AJ . Human lysosomal alpha-glucosidase. Characterization of the catalytic site . The Journal of Biological Chemistry . 266 . 21 . 13507–12 . July 1991 . 10.1016/S0021-9258(18)92727-4 . 1856189 . free .

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