Glycoside hydrolase family 10 explained

Symbol:	Glyco_hydro_10
Glycoside hydrolase, family 10
Pfam:	PF00331
Pfam Clan:	CL0058
Interpro:	IPR001000
Prosite:	PDOC00510
Scop:	2exo
Cazy:	GH10

In molecular biology, Glycoside hydrolase family 10 is a family of glycoside hydrolases.

Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.^{[1] [2] [3]} This classification is available on the CAZy web site,^{[4] [5]} and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.^{[6] [7]}

Glycoside hydrolase family 10 CAZY GH_10 comprises enzymes with a number of known activities; xylanase ; endo-1,3-beta-xylanase ; cellobiohydrolase . These enzymes were formerly known as cellulase family F.

The microbial degradation of cellulose and xylans requires several types of enzymes such as endoglucanases, cellobiohydrolases (exoglucanases), or xylanases .^{[8] [9]} Fungi and bacteria produces a spectrum of cellulolytic enzymes (cellulases) and xylanases which, on the basis of sequence similarities, can be classified into families. One of these families is known as the cellulase family F^[10] or as the glycosyl hydrolases family 10.^[11]

Notes and References

1. Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G . Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases . Proceedings of the National Academy of Sciences of the United States of America . 92 . 15 . 7090–4 . July 1995 . 7624375 . 41477 . 10.1073/pnas.92.15.7090 . 1995PNAS...92.7090H . free .
2. Davies G, Henrissat B . Structures and mechanisms of glycosyl hydrolases . Structure . 3 . 9 . 853–9 . September 1995 . 8535779 . 10.1016/S0969-2126(01)00220-9 . free .
3. Henrissat B, Bairoch A . Updating the sequence-based classification of glycosyl hydrolases . The Biochemical Journal . 316 . Pt 2 . 695–6 . June 1996 . 8687420 . 1217404 . 10.1042/bj3160695.
4. Web site: Home. CAZy.org. en. 2018-03-06.
5. Lombard V, Golaconda Ramulu H, Drula E, Coutinho PM, Henrissat B . The carbohydrate-active enzymes database (CAZy) in 2013 . Nucleic Acids Research . 42 . Database issue . D490-5 . January 2014 . 24270786 . 3965031 . 10.1093/nar/gkt1178 .
6. Web site: Glycoside Hydrolase Family 10. CAZypedia.org. en. 2018-03-06.
7. Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes . Glycobiology . 28 . 1 . 3–8 . December 2018 . 29040563 . 10.1093/glycob/cwx089 . CAZypedia Consortium . free . 21.11116/0000-0003-B7EB-6 . free .
8. Béguin P . Molecular biology of cellulose degradation . Annual Review of Microbiology . 44 . 219–48 . 1990 . 2252383 . 10.1146/annurev.mi.44.100190.001251 .
9. Gilkes NR, Henrissat B, Kilburn DG, Miller RC, Warren RA . Domains in microbial beta-1, 4-glycanases: sequence conservation, function, and enzyme families . Microbiological Reviews . 55 . 2 . 303–15 . June 1991 . 1886523 . 372816 . 10.1128/MMBR.55.2.303-315.1991.
10. Henrissat B, Claeyssens M, Tomme P, Lemesle L, Mornon JP . Cellulase families revealed by hydrophobic cluster analysis . Gene . 81 . 1 . 83–95 . September 1989 . 2806912 . 10.1016/0378-1119(89)90339-9 .
11. Henrissat B . A classification of glycosyl hydrolases based on amino acid sequence similarities . The Biochemical Journal . 280 . 2 . 309–16 . December 1991 . 1747104 . 1130547 . 10.1042/bj2800309 .