Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase explained

glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase
Ec Number:	2.4.1.122
Cas Number:	97089-61-7
Go Code:	0016263

In enzymology, a glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase is an enzyme that catalyzes the chemical reaction

UDP-galactose + glycoprotein N-acetyl-D-galactosamine

\rightleftharpoons UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine

Thus, the two substrates of this enzyme are UDP-galactose and glycoprotein N-acetyl-D-galactosamine, whereas its two products are UDP and glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase. This enzyme is also called uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase. This enzyme participates in o-glycan biosynthesis and glycan structures - biosynthesis 1.

See also

• C1GALT1

References

• Hesford FJ, Berger EG, Van den Eijnden DH . 1981 . Identification of the product formed by human erythrocyte galactosyltransferase . Biochim. Biophys. Acta . 659 . 302 - 11 . 6789880 . 2 . 10.1016/0005-2744(81)90056-5.
• Mendicino J, Sivakami S, Davila M, Chandrasekaran EV . 1982 . Purification and properties of UDP-gal:N-acetylgalactosaminide mucin: beta 1,3-galactosyltransferase from swine trachea mucosa . J. Biol. Chem. . 257 . 3987 - 94 . 6801057 . 7 . 10.1016/S0021-9258(18)34880-4 . free .
• Book: Schachter H, Narasimhan S, Gleeson P, Vella G . 1983 . Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type . Methods Enzymol. . 98 . 98 - 134 . 6366476 . 10.1016/0076-6879(83)98143-0 . 978-0-12-181998-9 .