Glycolipid transfer protein explained
Glycolipid transfer protein is a cytosolic protein that catalyses the transfer of glycolipids between different intracellular membranes.[1] [2]
It was discovered by Raymond J. Metz and Norman S. Radin in 1980 and partially purified and characterized in 1982.[3] [4]
Recent reviews on structure and possible function are available.[5] [6]
This protein transports primarily different glycosphingolipids and glyceroglycolipids between intracellular membranes, but not phospholipids. It might be also involved in translocation of glucosylceramides. It was found in brain, kidney, spleen, lung, cerebellum, liver and heart.
Human proteins containing this domain
GLTP
- PLEKHA8; PLEKHA9;
Notes and References
- Rao CS, Lin X, Pike HM, Molotkovsky JG, Brown RE . Glycolipid transfer protein mediated transfer of glycosphingolipids between membranes: a model for action based on kinetic and thermodynamic analyses . Biochemistry . 43 . 43 . 13805–15 . November 2004 . 15504043 . 2596630 . 10.1021/bi0492197 .
- Airenne TT, Kidron H, Nymalm Y, Nylund M, West G, Mattjus P, Salminen TA . Structural evidence for adaptive ligand binding of glycolipid transfer protein . Journal of Molecular Biology . 355 . 2 . 224–36 . January 2006 . 16309699 . 10.1016/j.jmb.2005.10.031 .
- Metz RJ, Radin NS . Glucosylceramide uptake protein from spleen cytosol . The Journal of Biological Chemistry . 255 . 10 . 4463–7 . May 1980 . 7372587 .
- Metz RJ, Radin NS . Purification and properties of a cerebroside transfer protein . The Journal of Biological Chemistry . 257 . 21 . 12901–7 . November 1982 . 7130186 .
- Mattjus P . Glycolipid transfer proteins and membrane interaction . Biochimica et Biophysica Acta (BBA) - Biomembranes . 1788 . 1 . 267–72 . January 2009 . 19007748 . 10.1016/j.bbamem.2008.10.003 .
- Brown RE, Mattjus P . Glycolipid transfer proteins . Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids . 1771 . 6 . 746–60 . June 2007 . 17320476 . 1986823 . 10.1016/j.bbalip.2007.01.011 .
