Glycitin Explained

Glycitin should not be confused with glycitein.

Glycitin (glycitein 7-O-glucoside) is an isoflavone found in soy, and remains to various degrees in soy products like tofu, soymilk[1] and soy sauce.[2] Although glycitin has its own health associated properties (below), it can be transformed to glycitein by human intestinal flora by the action of beta-glucosidases.[3]

Properties

Some interesting effects of glycitin include human dermal fibroblast cell proliferation and migration via TGF‐β signaling, glycitin treatment produces anti-photoaging effects such as collagen type I and collagen type III increase at both the mRNA and protein levels. Other noted effects decreased elastase, and decreased β‐galactosidase activation.[4] In conjunction with 4′,6,7-trimethoxyisoflavone (TMF), an isoflavone that promotes fibroblast migration but not proliferation, wound healing and anti-scarring activity (reorganization and wound fibrosis inhibition) were significantly and synergistically boosted in both in vivo mice and in vitro.[5]

Notes and References

  1. 10.1038/srep13018. 26260443. 4542527. Coagulation of β-conglycinin, glycinin and isoflavones induced by calcium chloride in soymilk. Scientific Reports. 5. 13018. 2015. Hsiao. Yu-Hsuan. Yu. Chia-Jung. Li. Wen-Tai. Hsieh. Jung-Feng. 2015NatSR...513018H.
  2. Web site: Health Benefits of Naturally Brewed Soy Sauce. 2018-04-04.
  3. Web site: Human Metabolome Database: Showing metabocard for Glycitin (HMDB0002219).
  4. 10.1002/ptr.5313. 25758427. Soy Isoflavone Glycitin (4'-Hydroxy-6-Methoxyisoflavone-7-D-Glucoside) Promotes Human Dermal Fibroblast Cell Proliferation and Migration via TGF-β Signaling. Phytotherapy Research. 29. 5. 757–769. 2015. Kim. Young Mee. Huh. Jung Sik. Lim. Yoongho. Cho. Moonjae. 206430410 .
  5. 10.1038/emm.2016.16. 27034026. 4855276. AMPK activators: Mechanisms of action and physiological activities. Experimental & Molecular Medicine. 48. 4. e224. 2016. Kim. Joungmok. Yang. Goowon. Kim. Yeji. Kim. Jin. Ha. Joohun.