Glycerol dehydrogenase (NADP+) explained

glycerol dehydrogenase (NADP^+)
Ec Number:	1.1.1.72
Cas Number:	37250-11-6
Go Code:	0047956

In enzymology, a glycerol dehydrogenase (NADP⁺) is an enzyme that catalyzes the chemical reaction

glycerol + NADP⁺

\rightleftharpoons D-glyceraldehyde + NADPH + H⁺

Thus, the two substrates of this enzyme are glycerol and NADP⁺, whereas its 3 products are D-glyceraldehyde, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is glycerol:NADP⁺ oxidoreductase. This enzyme is also called glycerol dehydrogenase (NADP⁺). This enzyme participates in glycerolipid metabolism.

References

• Kormann AW, Hurst RO, Flynn TG . 1972 . Purification and properties of an NADP⁺-dependent glycerol dehydrogenase from rabbit skeletal muscle . Biochim. Biophys. Acta . 258 . 40 - 55 . 4400494 . 1 . 10.1016/0005-2744(72)90965-5.
• Toews CJ . 1967 . The kinetics and reaction mechanism of the nicotinamide-adinine dinucleotide phosphate-specific glycerol dehydrogenase of rat skeletal muscle . Biochem. J. . 105 . 1067 - 1073 . 16742532 . 3 . 1198427.