Glycerol 2-phosphate explained

Glycerol 2-phosphate is the conjugate base of phosphoric ester of glycerol. It is commonly known as β-glycerophosphate or BGP. Unlike glycerol 1-phosphate and glycerol 3-phosphate, this isomer is not chiral. It is also less common.

Applications

β-Glycerophosphate is an inhibitor of the enzyme serine-threonine phosphatase. It is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition.^{[1] [2]}

β-Glycerophosphate is also used to drive osteogenic differentiation of bone marrow stem cells in vitro.^[3]

β-Glycerophosphate is used to buffer M17 media for Lactococcus culture in recombinant protein expression.^[4]

Notes and References

1. Web site: Sigma-Aldrich. β-Glycerophosphate disodium salt hydrate. 2018-05-30.
2. Web site: Thermo Fisher Scientific. Protease and Phosphatase Inhibitors. 2018-05-30.
3. Langenbach & Handschel. 2013. Effects of dexamethasone, ascorbic acid and β-glycerophosphate on the osteogenic differentiation of stem cells in vitro. Stem Cell Research & Therapy. 4. 5. 117. 10.1186/scrt328. 24073831. 3854789 . free .
4. Terzaghi & Sandine. 1975. Improved medium for lactic streptococci and their bacteriophages. Applied Microbiology. 29. 6. 807–813. 10.1128/AM.29.6.807-813.1975. 16350018. 187084.