Glycerol-1-phosphatase explained

glycerol-1-phosphatase
Ec Number:3.1.3.21
Cas Number:37228-75-4
Go Code:0000121

The enzyme glycerol-1-phosphatase (EC 3.1.3.21) catalyzes the reaction

glycerol 1-phosphate + H2O

\rightleftharpoons

glycerol + phosphate

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is glycerol-1-phosphate phosphohydrolase. Other names in common use include α-glycerophosphatase, α-glycerol phosphatase, glycerol 3-phosphatase, glycerol-3-phosphate phosphatase, and glycerol 3-phosphate phosphohydrolase. This enzyme participates in glycerolipid metabolism.

Among the organisms that have been shown to express this enzymatic activity are A. thaliana (plant) via the AtSgpp and AtGpp gene products;[1] D. salina (alga);[2] S. cerevisiae (fungus) via the GPP1/RHR2/YIL053W and GPP2/HOR2/YER062C gene products;[3] [4] C. albicans (fungus) via the GPP1 gene product;[5] M. tuberculosis (bacteria) via the rv1692 gene product;[6] and C57BL/6N mice and Wistar rats (mammals) via the PGP gene product.[7]

Notes and References

  1. September 2014. The kinetic analysis of the substrate specificity of motif 5 in a HAD hydrolase-type phosphosugar phosphatase of Arabidopsis thaliana. Planta. Abstract. 240. 3. 479 - 87. 10.1007/s00425-014-2102-6. 24915748. SpringerLink. Caparrós-Martín JA, McCarthy-Suárez I, Culiáñez-Macià FA. 2014Plant.240..479C . 8764480.
  2. 13 October 1981. Characterization and partial purification of DL-glycerol-1-phosphatase from Dunaliella salina. Biochimica et Biophysica Acta (BBA) - Enzymology. Abstract. 661. 2. 199 - 204. 10.1016/0005-2744(81)90004-8. 6252970. Sussman I, Avron M.
  3. 7 June 1996. Purification and Characterization of Two Isoenzymes of DL-Glycerol-3-phosphatase from Saccharomyces cerevisiae. Journal of Biological Chemistry. 271. 23. 13875 - 81. 8662716. Norbeck J, Påhlman AK, Akhtar N, et al. 10.1074/jbc.271.23.13875. free.
  4. 2 February 2001. The Yeast Glycerol 3-Phosphatases Gpp1p and Gpp2p Are Required for Glycerol Biosynthesis and Differentially Involved in the Cellular Responses to Osmotic, Anaerobic, and Oxidative Stress. Journal of Biological Chemistry. 276. 5. 3555 - 63. 10.1074/jbc.M007164200. 11058591. Påhlman AK, Granath K, Ansell R, et al. free.
  5. April 2005. Disruption of a gene encoding glycerol 3-phosphatase from Candida albicans impairs intracellular glycerol accumulation-mediated salt-tolerance. FEMS Microbiology Letters. 245. 107 - 16. 10.1016/j.femsle.2005.02.031. Oxford University Press. Fan J, Whiteway M, Shen SH. 1. 15796987. free.
  6. 25 June 2013. Discovery of a glycerol 3-phosphate phosphatase reveals glycerophospholipid polar head recycling in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 110. 28. 11320 - 5. 10.1073/pnas.1221597110. 3710836. 23801751. Larrouy-Maumus G, Biswas T, Hunt DM, et al. 2013PNAS..11011320L. free.
  7. 11 January 2016. Identification of a mammalian glycerol-3-phosphate phosphatase. Proceedings of the National Academy of Sciences of the United States of America. 113. E430 - 9. 10.1073/pnas.1514375113. 4743820. 26755581. Mugago Y, Zhao S, Seifried A, et al. 4. free.

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