Glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) explained

glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating)
Ec Number:	1.2.1.13
Cas Number:	37250-87-6
Go Code:	0047100

In enzymology, a glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) is an enzyme that catalyzes the chemical reaction

D-glyceraldehyde 3-phosphate + phosphate + NADP⁺

\rightleftharpoons 3-phospho-D-glyceroyl phosphate + NADPH + H⁺

The 3 substrates of this enzyme are D-glyceraldehyde 3-phosphate, phosphate, and NADP⁺, whereas its 3 products are 3-phospho-D-glyceroyl phosphate, NADPH, and H⁺.

Function

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. This enzyme participates in the Calvin cycle which is an autotrophic carbon fixation pathway.

Nomenclature

The systematic name of this enzyme class is D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase (phosphorylating). Other names in common use include:

• dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate) (phosphorylating)
• GAPDH
• glyceraldehyde phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) (phosphorylating)
• glyceraldehyde-3-phosphate dehydrogenase (NADP) (phosphorylating)
• NADP-dependent glyceraldehyde phosphate dehydrogenase
• NADP-glyceraldehyde phosphate dehydrogenase
• NADP-glyceraldehyde-3-phosphate dehydrogenase
• NADP-triose phosphate dehydrogenase
• triosephosphate dehydrogenase (NADP)

Further reading

• Brenneman FN, Volk WA . 1959 . Glyceraldehyde phosphate dehydrogenase activity with triphosphopyridine nucleotide and with diphosphopyridine nucleotide . J. Biol. Chem. . 234 . 9 . 2443 - 7 . 10.1016/S0021-9258(18)69832-1 . free . 13804190 .
• Book: Gibbs M . 1955 . [62] TPN triosephosphate dehydrogenase from plant tissue . Methods Enzymol. . 1 . 411 - 415 . 10.1016/0076-6879(55)01067-7. 978-0-12-181801-2 .
• Rosenberg LL, Arnon DI . 1955 . The preparation and properties of a new glyceraldehyde-3-phosphate dehydrogenase from photosynthetic tissues . J. Biol. Chem. . 217 . 361 - 71 . 13271400 . 1 . 10.1016/S0021-9258(19)57187-3 . free .