| Glutarate—CoA ligase | |
| Ec Number: | 6.2.1.6 |
| Cas Number: | 9023-68-1 |
| Go Code: | 0047948 |
In enzymology, a glutarate—CoA ligase is an enzyme that catalyzes the chemical reaction
ATP + glutarate + CoA
\rightleftharpoons
The 3 substrates of this enzyme are ATP, glutarate, and CoA, whereas its 3 products are ADP, phosphate, and glutaryl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is glutarate:CoA ligase (ADP-forming). Other names in common use include glutaryl-CoA synthetase, and glutaryl coenzyme A synthetase. This enzyme participates in fatty acid metabolism and lysine degradation.