Glutamate synthase (ferredoxin) explained

glutamate synthase (ferredoxin)
Ec Number:	1.4.7.1
Cas Number:	62213-56-3
Go Code:	0016041

In enzymology, a glutamate synthase (ferredoxin) is an enzyme that catalyzes the chemical reaction

2 L-glutamate + 2 oxidized ferredoxin

\rightleftharpoons L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H⁺

Thus, the two substrates of this enzyme are L-glutamate and oxidized ferredoxin, whereas its 4 products are L-glutamine, 2-oxoglutarate, reduced ferredoxin, and H⁺.

Classification

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH₂ group of donors with an iron-sulfur protein as acceptor.

Nomenclature

The systematic name of this enzyme class is L-glutamate:ferredoxin oxidoreductase (transaminating). Other names in common use include:

• ferredoxin-dependent glutamate synthase,
• ferredoxin-glutamate synthase,
• glutamate synthase (ferredoxin-dependent), and
• ferredoxin-glutamine oxoglutarate aminotransferase (Fd-GOGAT).

Biological role

This enzyme participates in nitrogen metabolism. It has 5 cofactors: FAD, iron, sulfur, iron-sulfur, and flavoprotein.

See also

• Glutamate synthase (NADH)
• Glutamate synthase (NADPH)

References

• Jang JE, Shaw K, Yu XJ, Petersen D, Pepper K, Lutzko C, Kohn DB . 2006 . Specific and stable gene transfer to human embryonic stem cells using pseudotyped lentiviral vectors . Stem Cells Dev. . 15 . 109 - 17 . 16522168 . 10.1089/scd.2006.15.109 . 1 .
• Lea PJ, Miflin BJ . 1974 . Alternative route for nitrogen assimilation in higher plants . Nature . 251 . 614 - 6 . 4423889 . 10.1038/251614a0 . 5476 . 1974Natur.251..614L . 4184284 .