Glutamate carboxypeptidase explained

Glutamate carboxypeptidase
Ec Number:3.4.17.11
Cas Number:9074-87-7

Glutamate carboxypeptidase (carboxypeptidase G, carboxypeptidase G1, carboxypeptidase G2, glutamyl carboxypeptidase, N-pteroyl-L-glutamate hydrolase) is an enzyme.[1] [2] [3] [4] This enzyme catalyses the following chemical reaction

Release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups

This zinc enzyme is produced by pseudomonads, Flavobacterium sp. and Acinetobacter sp.

See also

Notes and References

  1. Goldman P, Levy CC . Carboxypeptidase G: purification and properties . Proceedings of the National Academy of Sciences of the United States of America . 58 . 4 . 1299–306 . October 1967 . 5237864 . 223923 . 10.1073/pnas.58.4.1299 . 1967PNAS...58.1299G . free .
  2. McCullough JL, Chabner BA, Bertino JR . Purification and properties of carboxypeptidase G 1 . The Journal of Biological Chemistry . 246 . 23 . 7207–13 . December 1971 . 10.1016/S0021-9258(19)45873-0 . 5129727 . free .
  3. Albrecht AM, Boldizsar E, Hutchison DJ . Carboxypeptidase displaying differential velocity in hydrolysis of methotrexate, 5-methyltetrahydrofolic acid, and leucovorin . Journal of Bacteriology . 134 . 2 . 506–13 . May 1978 . 10.1128/jb.134.2.506-513.1978 . 26657 . 222280 .
  4. Sherwood RF, Melton RG, Alwan SM, Hughes P . Purification and properties of carboxypeptidase G2 from Pseudomonas sp. strain RS-16. Use of a novel triazine dye affinity method . European Journal of Biochemistry . 148 . 3 . 447–53 . May 1985 . 3838935 . 10.1111/j.1432-1033.1985.tb08860.x . free .

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