| glutaconyl-CoA decarboxylase | |
| Ec Number: | 7.2.4.5 |
| Cas Number: | 84399-93-9 |
| Go Code: | 0018801 |
In enzymology, a glutaconyl-CoA decarboxylase is an enzyme that catalyzes the chemical reaction[1]
(2E)-glutaconyl-CoA + H+ + Na+(in)
\rightleftharpoons
Hence, this enzyme has one substrate, (2E)-glutaconyl-CoA, and two products, (2E)-butenoyl-CoA and CO2. During the process, an sodium ion is transported across the membrane. Previously, this enzyme was classified as EC 4.1.1.70.[2]
This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 4-carboxybut-2-enoyl-CoA carboxy-lyase (but-2-enoyl-CoA-forming). Other names in common use include glutaconyl coenzyme A decarboxylase, pent-2-enoyl-CoA carboxy-lyase, and 4-carboxybut-2-enoyl-CoA carboxy-lyase. This enzyme participates in benzoate degradation via coa ligation and butanoate metabolism.
As a decarboxylase, the enzyme requires biotin for its function.
As of mid-2024, five structures have been solved for this class of enzymes, with the PDB accession codes,,, and .