Glucagon receptor family explained

The glucagon receptor family^[1] is a group of closely related G-protein coupled receptors which include:

• Glucagon receptor
  • Glucagon-like peptide 1 receptor Glucagon-like peptide 2 receptor
• Gastric inhibitory polypeptide receptor

The first three receptors bind closely related peptide hormones (glucagon, glucagon-like peptide-1, glucagon-like peptide-2) derived from the proglucagon polypeptide. The last receptor binds gastric inhibitory polypeptide.

References

1. Brubaker PL, Drucker DJ . Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors . Recept. Channels . 8 . 3–4 . 179–88 . 2002 . 12529935. 2008-07-14 . 10.1080/10606820213687.

External links

• Web site: Glucagon Receptors . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . https://web.archive.org/web/20180125072239/http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=29 . 2018-01-25 .