Glomerulopathy Explained

Glomerulopathy is diseases that impact the glomeruli in the nephron, either inflammatory or noninflammatory.^[1] Glomerulopathy includes collapsing glomerulopathy, glomerulocystic kidney disease, glomerulomegaly, membranous nephropathy, and tip lesion glomerulopathy.^[2]

Collapsing glomerulopathy (CG) is a clinicopathologic entity that involves hypertrophy and hyperplasia of podocytes and segmentar or global collapse of the glomerulus.^[3]

Glomerulocystic kidney disease is a rare form of renal cyst disease. Cortical microcysts, which are portrayed by cystic dilatation of Bowman's spaces, are its defining feature.^[4]

Glomerulomegaly is defined by unusually large glomeruli.^[5]

Membranous nephropathy (MN) is an uncommon autoimmune condition in which autoantibodies directed primarily against podocyte antigens target the glomerulus, causing electron-dense immune complexes to form, complement activation to occur, and severe proteinuria.^[6]

The glomerular tip lesion (GTL) is a unique histopathologic lesion that appears in idiopathic nephrotic syndrome patients.^[7]

See also

• Glomerulonephritis
• Glomerulonephrosis

Further reading

• Couser . William G. . Primary Membranous Nephropathy . Clinical Journal of the American Society of Nephrology . Ovid Technologies (Wolters Kluwer Health) . 12 . 6 . May 26, 2017 . 1555-9041 . 10.2215/cjn.11761116 . 983–997 . none . free. 28550082 . 5460716 .
• Ronco . Pierre . Beck . Laurence . Debiec . Hanna . Fervenza . Fernando C. . Hou . Fan Fan . Jha . Vivekanand . Sethi . Sanjeev . Tong . Allison . Vivarelli . Marina . Wetzels . Jack . Membranous nephropathy . Nature Reviews Disease Primers . Springer Science and Business Media LLC . 7 . 1 . September 30, 2021 . 2056-676X . 10.1038/s41572-021-00303-z . 34593809 . none.

Notes and References

1. Web site: Monarch Initiative . monarchinitiative.org . January 7, 2024.
2. Web site: Glomerulopathy (Concept Id: C0268731) . NCBI . October 31, 2023 . January 7, 2024.
3. Cutrim . Érico Murilo Monteiro . Neves . Precil Diego Miranda de Meneses . Campos . Marcos Adriano Garcia . Wanderley . Davi Campos . Teixeira-Júnior . Antonio Augusto Lima . Muniz . Monique Pereira Rêgo . Ladchumananandasivam . Francisco Rasiah . Gomes . Orlando Vieira . Vasco . Rafael Fernandes Vanderlei . Brito . Dyego José de Araújo . Lages . Joyce Santos . Salgado-Filho . Natalino . Guedes . Felipe Leite . de Almeida . José Bruno . Magalhães . Marcelo . Araújo . Stanley de Almeida . Silva . Gyl Eanes Barros . Collapsing Glomerulopathy: A Review by the Collapsing Brazilian Consortium . Frontiers in Medicine . Frontiers Media SA . 9 . March 3, 2022 . 2296-858X . 10.3389/fmed.2022.846173 . free . 35308512 . 8927620 .
4. Sahay . M. . Gowrishankar . S. . Glomerulocystic disease . Clinical Kidney Journal . Oxford University Press (OUP) . 3 . 4 . April 13, 2010 . 2048-8505 . 10.1093/ndtplus/sfq048 . 349–350 . free. 25949428 .
5. Hughson . M. D. . Hoy . W. E. . Douglas-Denton . R. N. . Zimanyi . M. A. . Bertram . J. F. . Towards a definition of glomerulomegaly: clinical-pathological and methodological considerations . Nephrology Dialysis Transplantation . Oxford University Press (OUP) . 26 . 7 . November 29, 2010 . 0931-0509 . 10.1093/ndt/gfq688 . 2202–2208 . free. 21115671 . 3164445 .
6. Ronco . Pierre . Plaisier . Emmanuelle . Debiec . Hanna . Advances in Membranous Nephropathy . Journal of Clinical Medicine . MDPI AG . 10 . 4 . February 5, 2021 . 2077-0383 . 10.3390/jcm10040607 . free . 607.
7. Stokes . M. Barry . Markowitz . Glen S. . Lin . Julie . Valeri . Anthony M. . D'Agati . Vivette D. . Glomerular tip lesion: A distinct entity within the minimal change disease/focal segmental glomerulosclerosis spectrum . Kidney International . Elsevier BV . 65 . 5 . 2004 . 0085-2538 . 10.1111/j.1523-1755.2004.00563.x . 1690–1702. 15086908 . free .