Glomeruloid hemangioma explained

Glomeruloid hemangioma is a distinctive vascular tumor first described in 1990 when found to be associated with POEMS syndrome and Castleman disease.^{[1] [2]} Glomeruloid hemangiomas can manifest as wine-red sessile or pedunculated papules, papulonodules, subcutaneous bluish compressible tumors, or small, firm, reddish-violaceous, dome-shaped papules.

Signs and symptoms

Glomeruloid hemangiomas can manifest as wine-red sessile or pedunculated papules, papulonodules, subcutaneous bluish compressible tumors, or small, firm, reddish-violaceous, dome-shaped papules.^[3] They mostly reside on the trunk and proximal limbs and range in size from a few millimeters to a few centimeters in diameter.^{[4] [5]} There have also been rare reports of glomeruloid hemangioma impacting the face.^{[6] [7]} There have also been reports of eruptive angiomatous lesions, which resemble eruptive histiocytomas.^[8]

Causes

Glomeruloid hemangiomas are most commonly associated with POEMS syndrome, occurring in up to 45% of individuals with POEMS syndrome.^[9] Glomeruloid hemangiomas have also been associated with TAFRO syndrome.^[10] Rarely glomeruloid hemangiomas can occur in individuals with no systematic conditions.^[11]

Diagnosis

The histopathologic examination displays well-defined, dispersed dermal structures in different sizes that have resemblance to renal glomeruli. The central vessel is bigger and has a sinusoidal appearance, and it is surrounded by a network of small capillary vessels on the periphery.^[12]

See also

• POEMS syndrome
• Hemangioma

Further reading

• González-Guerra . E. . Haro . M. R. . Fariña . M. C. . Martín . L. . Manzarbeitia . L. . Requena . L. . Glomeruloid haemangioma is not always associated with POEMS syndrome . Clinical and Experimental Dermatology . Oxford University Press (OUP) . 34 . 7 . 2009 . 0307-6938 . 10.1111/j.1365-2230.2008.02997.x . 800–803 . 19077091 . none.
• Phillips . Julie A. . Dixon . Julie E. . Richardson . Jeffrey B. . Fabre . Vilma C. . Callen . Jeffrey P. . Glomeruloid hemangioma leading to a diagnosis of POEMS syndrome . Journal of the American Academy of Dermatology . Elsevier BV . 55 . 1 . 2006 . 0190-9622 . 10.1016/j.jaad.2006.02.036 . 149–152 . 16781311 . none.

External links

• DermNet
• VisualDx

Notes and References

1. Book: James . William D. . Elston . Dirk . Treat . James R. . Rosenbach . Misha A. . Neuhaus . Isaac . Andrews' Diseases of the Skin: Clinical Dermatology . 2020 . Elsevier . Edinburgh. 978-0-323-54753-6 . 594 . 13th . https://books.google.com/books?id=UEaEDwAAQBAJ&dq=Dermal&pg=PA594 . en . 28. Dermal and subcutaneous tumors.
2. Book: Rapini, Ronald P. . Bolognia, Jean L. . Jorizzo, Joseph L. . Dermatology: 2-Volume Set . Mosby . St. Louis . 2007 . 978-1-4160-2999-1 .
3. Gupta . Jyoti . Kandhari . Rajat . Ramesh . V . Singh . Avninder . Glomeruloid hemangioma in normal individuals . Indian Journal of Dermatology . Medknow . 58 . 2 . 2013 . 0019-5154 . 10.4103/0019-5154.108088 . free . 160. 23716835 . 3657245 .
4. Puig . Lluis . Moreno . Abelardo . Domingo . Pere . Llistosella . Enric . de Moragas . José M. . Cutaneous angiomas in POEMS syndrome . Journal of the American Academy of Dermatology . Elsevier BV . 12 . 5 . 1985 . 0190-9622 . 10.1016/s0190-9622(85)70123-5 . 961–964. 3158680 .
5. Chan . P. T. . Lee . K. C. . Chong . L. Y. . Lo . K. K. . Cheung . Y. F. . Glomeruloid haemangioma with cerebriform morphology in a patient with POEMS syndrome . Clinical and Experimental Dermatology . Oxford University Press (OUP) . 31 . 6 . 2006 . 0307-6938 . 10.1111/j.1365-2230.2006.02213.x . 775–777. 17040261 .
6. Tsai . Chang-Yu . Lai . Chan-Ho . Chan . Heng-Leong . Kuo . Tseng-tong . Glomeruloid hemangioma –- a specific cutaneous marker of POEMS syndrome . International Journal of Dermatology . Wiley . 40 . 6 . 2001 . 0011-9059 . 10.1046/j.1365-4362.2001.01246-2.x . 403–406. 11589746 .
7. Yang . Seong Gyu . Cho . Kwang Hyun . Bang . Yung-Jue . Kim . Chul Woo . A Case of Glomeruloid Hemangioma Associated With Multicentric Castleman's Disease . The American Journal of Dermatopathology . Ovid Technologies (Wolters Kluwer Health) . 20 . 3 . 1998 . 0193-1091 . 10.1097/00000372-199806000-00008 . 266–270. 9650700 .
8. Perniciaro . Charles . POEMS syndrome . Seminars in Dermatology . Elsevier BV . 14 . 2 . 1995 . 0278-145X . 10.1016/s1085-5629(05)80013-6 . 162–165. 7640197 .
9. Book: Mocellin, Simone . Soft Tissue Tumors . Glomeruloid Hemangioma . Springer International Publishing . Cham . 2021 . 978-3-030-58709-3 . 10.1007/978-3-030-58710-9_112 . 377–378.
10. Shinozaki-Ushiku . Aya . Higashihara . Takaaki . Ikemura . Masako . Sato . Junichiro . Nangaku . Masaomi . Ushiku . Tetsuo . Fukayama . Masashi . Glomeruloid hemangioma associated with TAFRO syndrome . Human Pathology . Elsevier BV . 82 . 2018 . 0046-8177 . 10.1016/j.humpath.2018.04.011 . 172–176. 29702119 .
11. Roy . Rita R . Shimada . Katsumitsu . Hasegawa . Hiromasa . A Case of Oral Glomeruloid Hemangioma Without Systemic Conditions . Cureus . 2022-01-29 . 14 . 1 . e21705 . 2168-8184 . 35145824 . 8803383 . 10.7759/cureus.21705 . free .
12. Hernández Aragüés . I. . Pulido Pérez . A. . Ciudad Blanco . C. . Parra Blanco . V. . Suárez Fernández . R. . Glomeruloid Hemangioma and POEMS Syndrome . Actas Dermo-Sifiliográficas (English Edition) . Elsevier BV . 108 . 2 . 2017 . 1578-2190 . 10.1016/j.adengl.2016.12.006 . e15–e19. free .