Globoidnan A Explained

Globoidnan A is a lignan found in Eucalyptus globoidea, a tree native to Australia.

The molecule has been found to weakly inhibit the action of HIV integrase (IC₅₀ = 0.64 μM) in vitro.^[1] HIV integrase is an enzyme which is responsible for the introduction of HIV viral DNA into a host's cellular DNA. It is not known that globoidnan A inhibits the action of other retroviral integrases.

Notes and References

1. Ovenden SP, Yu J, Wan SS, etal . Globoidnan A: a lignan from Eucalyptus globoidea inhibits HIV integrase . . 65 . 24 . 3255–59 . 2004 . 15561191 . 10.1016/j.phytochem.2004.10.006 .