Gliquidone Explained

Gliquidone (INN, sold under the trade name Glurenorm) is an anti-diabetic medication in the sulfonylurea class.^[1] It is classified as a second-generation sulfonylurea. It is used in the treatment of diabetes mellitus type 2. It is marketed by the pharmaceutical company Boehringer Ingelheim (Germany).

Contraindications

• Allergy to sulfonylureas or sulfonamides
• Diabetes mellitus type 1
• Diabetic ketoacidosis
• Patients that underwent removal of the pancreas
• Acute porphyria
• Severe liver disease accompanying with liver insufficiency
• Several conditions (e.g., infectious diseases or major surgical intervention), when insulin administration is required
• Pregnancy or breastfeeding^[2]

Pharmacokinetics

Gliquidone is fully metabolized by the liver. Its metabolites are excreted virtually completely with bile (even with long-term administration), thus allowing the use of medication in diabetic patients with kidney disease and diabetic nephropathy.

Notes and References

1. Malaisse WJ . Gliquidone contributes to improvement of type 2 diabetes mellitus management: a review of pharmacokinetic and clinical trial data . Drugs in R&D . 7 . 6 . 331–7 . 2006 . 17073516 . 10.2165/00126839-200607060-00002 . 10155445 .
2. Web site: Glurenorm (gliquidone) 30 mg Tablets, for Oral Use. Full Prescribing Information. Russian State Register of Medicinal Products. Boehringer Ingelheim. 12 July 2016. ru. https://web.archive.org/web/20160814064150/http://grls.rosminzdrav.ru//InstrImgMZ/PN/P%20N014529_01/2.INS/014529_002.gif. 14 August 2016. dead.