Glionitrin A Explained

Glionitrin A is an antibiotic-anticancer compound made by microbes found in an abandoned mine.^[1] The total synthesis of (−)-glionitrin A was reported by Daniel Strand and co-workers in 2021.^[2]

Notes and References

1. 19159274 . Glionitrin A, an antibiotic-antitumor metabolite derived from competitive interaction between abandoned mine microbes . 10.1021/np800606e . 72 . 2 . February 2009 . J. Nat. Prod. . 248–52. Park . H. B. . Kwon . H. C. . Lee . C. H. . Yang . H. O. .
2. Total Synthesis of (−)-Glionitrin A and B Enabled by an Asymmetric Oxidative Sulfenylation of Triketopiperazines . 10.1021/jacs.1c10364 . 143. 50. 22 November 2021 . J. Am. Chem. Soc. . 21218–21222. Koning. N.R. . Sundin . A.P. . Strand . D. . 34808045 . 8704193 .