Glidant Explained

A glidant is a substance that is added to a powder to improve its flowability. A glidant will only work at a certain range of concentrations. Above a certain concentration, the glidant will in fact function to inhibit flowability.

In tablet manufacture, glidants are usually added just prior to compression.

Examples

Examples of glidants include ascorbyl palmitate,[1] calcium palmitate,[2] magnesium stearate, fumed silica (colloidal silicon dioxide), starch and talc.[3]

Mechanism of action

A glidant's effect is due to the counter-action of factors that cause poor flowability of powders. For instance, correcting surface irregularity, reducing interparticular friction and decreasing surface charge. The result is a decrease in the angle of repose which is an indication of an enhanced powder's flowability.

Notes and References

  1. Use of ascorbyl palmitate and ascorbyl stearate as glidant for tablets. KR. 101440100. 2014-09-17. Cosmax Bio Co. Ltd.. Kim. Dong Sup. Baik. Joo Hyun. Jung. Hyun Mook. Lee, Jae Hyun;Lee, Kyung Jin.
  2. Web site: Vitamin & Supplement Recommendations for Your Health Concerns - Swanson®. 2021-02-05. www.swansonvitamins.com. 2021-02-28. https://web.archive.org/web/20210228165511/https://www.swansonvitamins.com/quality/additives-fillers.html. live.
  3. Web site: SMI: Talc as a Glidant & Lubricant. 2012 Specialty Minerals Inc.. 19 March 2014. 28 August 2008. https://web.archive.org/web/20080828023520/http://www.specialtyminerals.com/specialty-applications/specialty-markets-for-minerals/nutritional-supplements/talc-as-a-glidant-lubricant/. live.

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