Glibornuride Explained

Glibornuride (INN) is an anti-diabetic drug from the group of sulfonylureas.[1] It is manufactured by MEDA Pharma and sold in Switzerland under the brand name Glutril.[2]

Synthesis

Gliburnide is an endo-endo derivative made from camphor-3-carboxamide by borohydride reduction (exo approach), followed by Hofmann rearrangement to carbamate, followed by displacement with sodium tosylamide.

Notes and References

  1. Haupt E, Köberich W, Beyer J, Schöffling K . Pharmacodynamic aspects of tolbutamide, glibenclamide, glibornuride and glisoxepide. I. Dose response relations and repeated administration in diabetic subjects . Diabetologia . 7 . 6 . 449–54 . December 1971 . 5004178 . 10.1007/bf01212061. free .
  2. Web site: Glutril — Drugs.com. Drugs.com. 12 July 2016. 14 September 2016. https://web.archive.org/web/20160914204342/https://www.drugs.com/international/glutril.html. live.

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