Glaize Creek (also called Grand Glaize Creek) is a stream in Jefferson County in the U.S. state of Missouri. It is a tributary of the Mississippi River. The stream headwaters arise at 38.3703°N -90.4936°W just east of Missouri Route 21. The stream flows east-southeast roughly paralleling Missouri Route M and passes under I-55 north of Barnhart then passing under US Route 61 to its confluence with the Mississippi River adjacent to Sulphur Springs[1] at 38.3342°N -90.3742°W.
Glaize Creek derives its name from the French words denoting "red earth".[2]