Gisou van der Goot explained

Gisou van der Goot
Birth Name:Françoise Gisou van der Goot
Birth Date:19 September 1964
Birth Place:Tehran, Iran
Fields:Biology
Workplaces:École Polytechnique Fédérale de Lausanne (EPFL)
Alma Mater:École Centrale de Paris
Thesis Title:Role Respectif des Membranes Apicales et Basolaterales dans les Mecanismes de Transfport d'eau a Travers les Structures Epitheliales
Thesis Url:https://www.worldcat.org/oclc/490425893
Thesis Year:1990
Doctoral Advisors:)-->
Spouse:Jean Gruenberg
Partners:)-->

Françoise Gisou van der Goot (born 19 September 1964 in Tehran)[1] is a Swiss-Dutch cell biologist. She is a professor and the Vice President for Responsible Transformation at EPFL (École Polytechnique Fédérale de Lausanne).[2]

Career

Gisou van der Goot studied engineering at the École Centrale de Paris. She pursued a PhD in molecular biophysics at the Saclay Nuclear Research Centre (Pierre and Marie Curie University).[3] After her PhD, she was a postdoctoral researcher at the European Molecular Biology Laboratory (EMBL) in Heidelberg. In 1994 she worked as a group leader in the Department of Biochemistry of the University of Geneva and, subsequently, from 2001 as associate professor in the department of microbiology and molecular medicine. Since 2006, she has been full professor of molecular and cellular microbiology at the School of Life Sciences of EPFL,[4] [5] where she was also dean until 2020.[6] In September 2020, she was appointed Vice President for Responsible Transformation at EPFL for a term starting in 2021.

Research

Gisou van der Goot leads the Laboratory of Cell and Membrane Biology at the School of Life Sciences of the École Polytechnique Fédérale de Lausanne (EPFL).[7] Her laboratory studies various aspects of cellular and intracellular membrane dynamics. Notably, it aims to better understand the way protein palmitoylation regulates endoplasmic reticulum function and protein trafficking,[8] the mechanisms which allow bacterial proteins such as the anthrax toxin to penetrate target cells,[9] and the molecular mechanisms leading to juvenile hyaline fibromatosis, a rare and debilitating genetic disorder.[10] In the context of the COVID-19 pandemic, Gisou van der Goot declared to have dedicated part of her laboratory to study SARS-CoV-2.[11]

Awards and honors

Gisou van der Goot obtained a European Molecular Biology Organization (EMBO) Young Investigator award[12] in 2001 and an Howard Hughes International Scholar award in 2005. In 2009, she received the Leenaards Foundation Research Prize[13] and the Marcel Benoist Prize.[14] The latter two prizes were awarded for her contributions to the biochemistry of the bacterial toxin of the anthrax pathogen at the host cell membrane. In 2020, she was awarded the Suffrage Science award.[15]

She has been member of scientific boards such as the Swiss National Science Foundation,[16] the Swiss Science Council and the European Research Council (ERC).

Selected works

Personal life

Gisou van der Goot is married to Swiss biologist Jean Gruenberg and has two children.

External links

Notes and References

  1. Web site: Françoise Gisou van der Goot reçoit le Prix Marcel Benoist 2009. 2020-08-01. admin.ch.
  2. Web site: Board appoints new members of the Executive Boards of ETH Zurich and EPFL ETH-Board. 2020-09-25. ethrat.ch. 2021-04-20. https://web.archive.org/web/20210420154907/https://www.ethrat.ch/en/media/releases/board-appoints-new-members-of-the-executive-boards-of-eth-zurich-and-epfl. dead.
  3. Web site: ORCID. Gisou van der Goot (0000-0002-8522-274X). 2021-01-20. orcid.org. en.
  4. Web site: Gisou van der Goot. 2020-07-29. people.epfl.ch.
  5. Web site: Van der Goot Lab ‐ EPFL. 2020-07-29. en-GB.
  6. Evangelista. Sandy. 2020-04-06. "The most important thing is staying in touch". en.
  7. Web site: van der Goot Lab – Laboratory of Cell and Membrane Biology. 2020-08-13. epfl.ch. en-GB.
  8. Blaskovic. Sanja. Blanc. Mathieu. Goot. F. Gisou van der. 2013. What does S-palmitoylation do to membrane proteins?. The FEBS Journal. en. 280. 12. 2766–2774. 10.1111/febs.12263. 23551889 . 1742-4658. free.
  9. Abrami. Laurence. Liu. Shihui. Cosson. Pierre. Leppla. Stephen H.. van der Goot. F. Gisou. 2003. Anthrax toxin triggers endocytosis of its receptor via a lipid raft–mediated clathrin-dependent process. Journal of Cell Biology. en. 160. 3. 321–328. 10.1083/jcb.200211018. 0021-9525. free. 12551953 . 2172673.
  10. Deuquet. Julie. Lausch. Ekkehart. Guex. Nicolas. Abrami. Laurence. Salvi. Suzanne. Lakkaraju. Asvin. Ramirez. Maria Celeste M.. Martignetti. John A.. Rokicki. Dariusz. Bonafe. Luisa. Superti-Furga. Andrea. 2011. Hyaline Fibromatosis Syndrome inducing mutations in the ectodomain of anthrax toxin receptor 2 can be rescued by proteasome inhibitors. EMBO Molecular Medicine. 3. 4. 208–221. 10.1002/emmm.201100124. 1757-4676. 3377065. 21328543.
  11. News: 2020-07-02. Gisou van der Goot, de l'anthrax au Covid-19. fr. Le Temps. 2020-08-13. 1423-3967.
  12. Web site: Find an EMBO Young Investigator / EMBO Installation Grantee / EMBO Global Investigator. 2020-07-29. yip-search.embo.org.
  13. Web site: Etude des mécanismes amenant des pathogènes à être mortels pour l'homme. 2020-07-29. Fondation Leenaards - Favoriser la dynamique créatrice. fr.
  14. Web site: Past laureates – Marcel Benoist Foundation. 2020-08-01. marcel-benoist.ch.
  15. Web site: Arthur. Sophie. 2020-10-22. Life Sciences Awardee 2020: Professor Gisou van der Goot. 2020-10-23. suffragescience. en.
  16. Web site: Former SSC members. 2020-07-29. swir.ch.

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