Girentuximab Explained

Girentuximab (trade name Rencarex) is a chimeric IgG1 monoclonal antibody to carbonic anhydrase IX (CAIX).[1] CAIX is expressed on the surface of most renal cancer cells and is hypothesized to be on the surface of other tumor cells. It is investigational agent in clinical trials for renal cell carcinoma.[2] Its development was suspended as a "naked" or unconjugated antibody during phase III trials due to efficacy.[3] [4]

Girentuximab was originally developed by Wilex AG, Germany. It was granted fast track status and orphan drug designation by the FDA for renal cancer.[5] In January 2017, Telix Pharmaceuticals Limited, an Australian biotechnology company, announced that it had in-licensed Girentuximab for use as a radioimmunoconjugate.[6]

It triggers antibody-dependent cell-mediated cytotoxicity (ADCC). When it binds to its antigen (carbonic anhydrase IX), it activates natural killer cells by binding to a receptor on the NK cells.[7]

References

  1. Web site: Statement On A Nonproprietary Name Adopted By The USAN Council: Girentuximab. American Medical Association.
  2. Bedke J, Stenzl A . Immunotherapeutic strategies for the treatment of renal cell carcinoma: where are we now? . Expert Review of Anticancer Therapy . 13 . 12 . 1399–408 . 2013 . 24215158 . 10.1586/14737140.2013.856761 . 30585644 .
  3. Web site: A Randomized, Double Blind Phase III Study to Evaluate Adjuvant cG250 Treatment Versus Placebo in Patients with Clear Cell RCC and High Risk of Recurrence (ARISER). 31 October 2018.
  4. News: Cyclacel's cancer drug isn't working in Phase III, but that won't stop the trial. Fierce Biotech . 16 December 2014 .
  5. adisinsight.springer.com/drugs/800006571
  6. Web site: WILEX signs antibody license agreement with Telix Pharmaceuticals Limited WILEX AG. www.wilex.de. de-DE. 2017-09-18. 2017-09-18. https://web.archive.org/web/20170918110556/http://www.wilex.de/press-investors/announcements/press-releases/20170116-2/. dead.
  7. Web site: Girentuximab (Rencarex) for renal cell carcinoma . 2016-03-04 . 2016-03-06 . https://web.archive.org/web/20160306180558/http://www.hsric.nihr.ac.uk/topics/girentuximab-rencarex-for-renal-cell-carcinoma/ . dead .

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