CCDC88A explained

Girdin is a protein that in humans is encoded by the CCDC88A gene.^{[1] [2] [3]} Although its cellular function are not fully elucidated, it has been associated with glioma.^[4]

External links

• DISC1 Players Gird For Adult Neurodevelopment - Schizophrenia Research Forum, 8 oct 2009

Further reading

• Kitamura T, Asai N, Enomoto A . Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin. . Nat. Cell Biol. . 10 . 3 . 329–37 . 2008 . 18264090 . 10.1038/ncb1695 . 23157573 . etal.
• Enomoto A, Murakami H, Asai N . Akt/PKB regulates actin organization and cell motility via Girdin/APE. . Dev. Cell . 9 . 3 . 389–402 . 2005 . 16139227 . 10.1016/j.devcel.2005.08.001 . etal. free .
• Simpson F, Martin S, Evans TM . A novel hook-related protein family and the characterization of hook-related protein 1. . Traffic . 6 . 6 . 442–58 . 2005 . 15882442 . 10.1111/j.1600-0854.2005.00289.x . 25389776 . etal. free .
• Ballif BA, Villén J, Beausoleil SA . Phosphoproteomic analysis of the developing mouse brain. . Mol. Cell. Proteomics . 3 . 11 . 1093–101 . 2005 . 15345747 . 10.1074/mcp.M400085-MCP200 . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Nagase T, Ishikawa K, Kikuno R . Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 6 . 5 . 337–45 . 2000 . 10574462 . 10.1093/dnares/6.5.337 . etal. free .

Notes and References

1. Le-Niculescu H, Niesman I, Fischer T, DeVries L, Farquhar MG . Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles . J Biol Chem . 280 . 23 . 22012–20 . Jun 2005 . 15749703 . 10.1074/jbc.M501833200 . free .
2. Anai M, Shojima N, Katagiri H, Ogihara T, Sakoda H, Onishi Y, Ono H, Fujishiro M, Fukushima Y, Horike N, Viana A, Kikuchi M, Noguchi N, Takahashi S, Takata K, Oka Y, Uchijima Y, Kurihara H, Asano T . A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis . J Biol Chem . 280 . 18 . 18525–35 . May 2005 . 15753085 . 10.1074/jbc.M500586200 . free .
3. Web site: Entrez Gene: KIAA1212 KIAA1212.
4. Girdin, an actin-binding protein, is critical for migration, adhesion, and invasion of human glioblastoma cells . 25060559 . 2014 . Gu . F. . Wang . L. . He . J. . Liu . X. . Zhang . H. . Li . W. . Fu . L. . Ma . Y. . Journal of Neurochemistry . 131 . 4 . 457–469 . 10.1111/jnc.12831 . 206090300 .