| Type: | Cardinal |
| Honorific Prefix: | His Eminence |
| Giovanni Serafini | |
| Cardinal-Deacon of Santa Maria in Cosmedin | |
| Church: | Roman Catholic Church |
| Appointed: | 16 April 1846 |
| Term End: | 1 February 1855 |
| Predecessor: | Paolo Mangelli Orsi |
| Successor: | Giuseppe Ugolini |
| Cardinal: | 27 January 1843 |
| Created Cardinal By: | Pope Gregory XVI |
| Rank: | Cardinal-Deacon |
| Birth Name: | Giovanni Serafini |
| Birth Date: | 15 October 1786 |
| Birth Place: | Magliano Sabina, Papal States |
| Death Place: | Rome, Papal States |
| Buried: | Santa Maria in Cosmedin |
| Previous Post: | Cardinal-Priest of Santi Vito, Modesto e Crescenzio (1843-46) |
Giovanni Serafini (15 October 1786 - 1 February 1855) was an Italian Cardinal. He was the Cardinal-Deacon of Santi Vito, Modesto e Crescenzio from 1843 to 1846 and then the Cardinal-Deacon of Santa Maria in Cosmedin from 1846 until his death in 1855.