| Type: | Bishop |
| Honorific-Prefix: | Most Reverend |
| Giovanni Leonardo Bottiglieri | |
| Bishop of Lettere-Gragnano | |
| Church: | Catholic Church |
| Diocese: | Diocese of Lettere-Gragnano |
| Term: | 1591–1599 |
| Predecessor: | Giovanni Bernardino Grandopoli |
| Successor: | Francesco Brusco |
| Consecration: | 3 February 1591 |
| Consecrated By: | Filippo Spinola |
| Death Date: | 1599 |
| Death Place: | Lettere, Italy |
Giovanni Leonardo Bottiglieri (died 1599) was a Roman Catholic prelate who served as Bishop of Lettere-Gragnano (1591–1599).
On 14 January 1591, Giovanni Leonardo Bottiglieri was appointed during the papacy of Pope Gregory XIV as Bishop of Lettere-Gragnano. On 3 February 1591, he was consecrated bishop by Filippo Spinola, Cardinal-Priest of Santa Sabina, with César Alamagna Cardona, Bishop of Cava de' Tirreni, and Owen Lewis (bishop), Bishop of Cassano all'Jonio, serving as co-consecrators. He served as Bishop of Lettere-Gragnano until his death in 1599.