| Type: | Bishop |
| Honorific-Prefix: | Most Reverend |
| Giovanni Bernardino Grandopoli | |
| Bishop of Lettere-Gragnano | |
| Church: | Catholic Church |
| Diocese: | Diocese of Lettere-Gragnano |
| Term: | 1576–1590 |
| Predecessor: | Aurelio Griani |
| Successor: | Giovanni Leonardo Bottiglieri |
| Consecration: | 4 November 1576 |
| Consecrated By: | Giulio Antonio Santorio |
| Death Date: | 1590 |
| Death Place: | Lettere, Italy |
Giovanni Bernardino Grandopoli (died 1590) was a Roman Catholic prelate who served as Bishop of Lettere-Gragnano (1576–1590).
On 19 September 1576, Giovanni Bernardino Grandopoli was appointed during the papacy of Pope Gregory XIII as Bishop of Lettere-Gragnano. On 4 November 1576, he was consecrated bishop by Giulio Antonio Santorio, Cardinal-Priest of San Bartolomeo all'Isola, with Cesare de' Giacomelli, Bishop of Belcastro, and Gaspare Viviani, Bishop of Hierapetra et Sitia, serving as co-consecrators. He served as Bishop of Lettere-Gragnano until his death in 1590. While bishop, he was the principal co-consecrator of Francesco D'Afflitto, Bishop of Scala (1583).