| Honorific-Prefix: | Most Reverend |
| Giovanni Antonio Santorio | |
| Bishop of Policastro | |
| Church: | Catholic Church |
| Diocese: | Diocese of Policastro |
| Term: | 1610–1628 |
| Predecessor: | Ilario Cortesi |
| Successor: | Urbano Felicio |
| Death Date: | May 1628 |
| Death Place: | Policastro, Italy |
Giovanni Antonio Santorio (died May 1628) was a Roman Catholic prelate who served as Bishop of Policastro (1610–1628).
On 26 April 1610, Giovanni Antonio Santorio was appointed by Pope Paul V as Bishop of Policastro. He served as Bishop of Policastro until his death in May 1628. While bishop, he was the principal co-consecrator of Benedikt Orsini, Bishop of Lezhë, and Pietro Budi, Bishop of Sapë.