Gingipain Explained

Gingipains are a family of proteases secreted by Porphyromonas gingivalis. Among other functions, it works to degrade cytokines, thereby downregulating the host response in the form of reduced inflammation.^[1] Gingipain has been studied for its potential role in the development of Alzheimer's disease.^{[2] [3]}

See also

• Gingipain R
• Gingipain K

Notes and References

1. Stathopoulou, PG. Epithelial cell pro-inflammatory cytokine response differs across dental plaque bacterial species. J Clin Perio 2010;37:24–29
2. https://www.science.org/doi/10.1126/sciadv.aau3333 Dominy, S.S., Lynch, C., Ermini, F., Benedyk, M., Marczyk, A., Konradi, A., Nguyen, M., Haditsch, U., Raha, D., Griffin, C. and Holsinger, L.J., 2019. Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Science Advances, 5(1), p.eaau3333.
3. https://www.newscientist.com/article/2191814-we-may-finally-know-what-causes-alzheimers-and-how-to-stop-it/ New Scientist 29 January 2019