Gilles-Éric Séralini Explained

Gilles-Éric Séralini
Birth Date:23 August 1960
Birth Place:Bône, Algeria (then French Algeria)
Fields:Endocrinology
Workplaces:University of Caen
Alma Mater:University of Montpellier II
Thesis Title:Rôle inhibiteur de l'alphafoetoprotéine sur la fonction génitale du rat
Thesis Url:https://www.worldcat.org/oclc/468738179
Thesis Year:1987
Known For:Séralini affair
Awards:Knight of the National Order of Merit, Denis Guichard prize, Theo Colborn Award, whistleblower award, International Scientist of the Year.
Spouse:Soline Séralini[1]
Children:Two

Gilles-Éric Séralini (born 23 August 1960) is a French molecular biologist, political advisor and activist on genetically modified organisms and foods. He is of Algerian-French origin. Séralini has been a professor of molecular biology at the University of Caen since 1991, and is president and chairman of the board of CRIIGEN.[2]

His work and publication strategies on GMOs have been controversial.[3] A paper he published in 2012 attracted major controversy and was retracted by the journal.

Early life

Séralini was born on 23 August 1960 in Bône, Algeria, during the Algerian War of Independence. His father was a telecommunications technician and his mother was a schoolteacher.[4] His family soon settled in Thonon-les-Bains, Haute Savoie, and then Nice, France.

Career

In 1987, Séralini obtained his doctoral degree from the University of Montpellier II. He then did four years of research at, among other places, the University of Western Ontario and Laval University Medical Center. Séralini underwent research on corticosteroid-binding globulin, before being appointed a professor at the University of Caen in June 1991, a position he has held ever since. The general area of his lab's research focuses on the endocrine system,[5] in particular the enzyme aromatase. His lab has synthesized a number of aromatase inhibitors using equine aromatase as a model.[6] His research has been published in the Journal of Histochemistry & Cytochemistry, the Journal of Steroid Biochemistry and Molecular Biology, and Molecular and Cellular Endocrinology.

In 1997, he became interested in genetically modified organisms, publicly appealing for the precautionary principle to be followed. He was appointed to various government posts, including roles in the French government, the European Union and the European Commission.[7] From 1998 till 2007 Séralini was a member of the French Biomolecular Engineering Commission which was tasked with evaluating GMO allowances for both the French Ministry of Agriculture and Ministry of the Environment.

CRIIGEN

Séralini founded the Committee of Research and Independent Information on Genetic Engineering (CRIIGEN) with Corine Lepage, a former politician, and Pierre-Henri Gouyon, a professor from the Muséum national d'histoire naturelle, in 1999. CRIIGEN is publicly opposed to genetically modified food (GM food).[8] [9] [10] Séralini founded CRIIGEN because he judged that studies on GM food safety were inadequate, and questioned their acceptance.[8]

In 2007, Séralini and two other authors from the University of Caen and the University of Rouen published a Greenpeace-funded paper using data obtained from rat feeding studies conducted by Monsanto in 2004.[11] [12] [13] They concluded that the genetically modified maize used, MON 863, resulted in significant variations to the control rats weight, triglyceride levels and urine composition. They also concluded it effected the liver, kidney, adrenal glands, heart, and haematopoietic system and recommended that safety experiments continue beyond 90 days. Greenpeace cited the study in a press release calling for MON 863's recall and a review of testing methods.[14]

The paper prompted the European Food Safety Authority (EFSA) to reexamine the MON 863 safety data. It asked EU countries for any new data about the strain, new opinions on the original Monsanto study and a technical meeting with the authors of the 2007 CRIIGEN paper. The EFSA concluded that all blood chemistry and organ weight values fell within the normal range for the control animals in question[15] and that the Séralini paper used incorrect statistical methods.[16] In 2010 Markos Kyprianou (European Commissioner for Health and Consumer Policy) confirmed the doubts in a report to the European Parliament.[17] The French Commission du Génie Biomoléculaire (AFBV) also reached critical conclusions.[18] "Food Standards Australia New Zealand attributed the differences between rats fed MON 863 corn and control rats to normal biological variation (for the species in question)."[19] [20]

In 2009, the Séralini lab published another study, which re-analyzed toxicity data for glyphosate resistant, MON 810 and MON 863 strains, concluded that they showed liver, kidney and heart damages in the rats.[21] EFSA found no base for the claims and saw many of the statistical criticisms of the 2007 paper applying to the 2009 paper also.[22] The French (HCB) concluded that Séralini 2009 "..presents no admissible scientific element likely to ascribe any haematological, hepatic or renal toxicity to the three re-analysed GMOs."[23] Food Standards Australia New Zealand had a similar result.[24] The HCB also questioned the authors' independence.[23]

A 2011 review by Séralini, using data from 19 published animal feeding studies and several animal feeding studies submitted for regulatory approval, continued to conclude that GM food had liver and kidney effects, and advocated for longer and more elaborate toxicology tests for regulatory approval.[25]

2012 paper

See main article: Séralini affair. On 19 September 2012, Séralini and his colleagues published a peer-reviewed paper funded by CRIIGIN titled "Long-term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize" in Food and Chemical Toxicology (FCT).[26] It involved a two-year study of genetically modified corn and the herbicide RoundUp fed to rats.[27] At a press conference announcing his paper, Séralini emphasized the study's potential cancer implications. Photographs from the journal article of treated rats with large tumors were widely circulated in the press.[28] In November 2013, the FCT editors retracted the paper,[29] with the editor-in-chief saying that its results were inconclusive.[27] [30] In June 2014 the text of the article was republished in Environmental Sciences Europe.[31]

With a few exceptions, the scientific community dismissed the Séralini study and called for a more rigorous peer-review system in scientific journals.[32]

After Séralini published his 2012 corn study in parallel with a book and a documentary called Tous Cobayes !, various French Academies wrote a common bulletin expressing a number of concerns related to the study. The bulletin criticizes the science behind the study, questions the ethics of the study's authors and the standards of the publishing journal (Food and Chemical Toxicology), and states concern over the social consequences of what the bulletin's authors perceive to be scaremongering in the area of GMOs. Signatories of the bulletin included the Académie d'agriculture de France, Académie nationale de médecine, Académie nationale de pharmacie, Académie des sciences, Académie des technologies and Académie vétérinaire de France.[33]

Recent work

In May 2013, shortly before a debate was scheduled to take place on the topic of genetically modified foods, held by the libertarian think tank Cato Institute, both Séralini and consumer activist Jeffrey M. Smith withdrew from the debate. Smith disapproved of the planned inclusion of molecular biologist Kevin Folta and Séralini accused Jon Entine, who organized the debate's panel, of libel.[34]

In 2014, Séralini et al. published a study claiming that pesticides were more toxic than regulatory bodies had previously thought.[35] The study prompted Ralf Reski, one of the editors of BioMed Research International, the journal in which it was published, to resign. Reski said, "I do not want to be connected to a journal that provides [Séralini] a forum for such kind of agitation."[36]

Various journalists criticized Séralini's strategy towards the public, since he asked media to sign non-disclosure agreements before the publishing and tried to interdict requests to other scientists. The publication strategy overall has been deemed flawed and questionable again, as it connected allegedly flawed scientific studies, various publications, books and films in parallel while trying to silence scientific and public debate in a broad political campaign of questionable value.[37] [38]

A 2016 paper published by Seralini claims homeopathic remedies protect against acute glyphosate intake alleged toxicity.[39] This claim is without any scientific basis or evidence. A strong consensus prevails among the scientific community that homeopathy is a pseudo-scientific,[40] [41] [42] [43] unethical[44] [45] and implausible line of treatment.[46] [47] [48] [49]

Supporters and funding

Gilles-Eric Séralini has published various studies and a book Nous pouvons nous dépolluer (We are able to detox ourselves, 2009) claiming certain plant based pharmaceuticals based on homeopathy were being able to decrease poisonous influences.[50] The related lab received funding from Sevene Pharma to study the detoxifying capacity of their plant extracts on Roundup residues, bisphenol A and atrazine. Séralini participated and received payment for a lecture in a two-day seminar organized by Sevene Pharma.[51]

In 2010, Séralini sued University of Paris VII, president of the and the Association, for libel, claiming that they had unjustly criticized his scientific ability and his research because of its funder, Greenpeace. The judge ruled that because Fellous and other critics had financial ties to the agricultural biotechnology industry, their charge about the Greenpeace funding was defamatory, but refused to rule on the scientific matter. Fellous was fined 1000 euros. Séralini was awarded a symbolic 1 euro in damages and court costs.[52]

Awards and honors

Selected publications

Scientific papers

Books

Notes and References

  1. Web site: Gilles-Eric Seralini: The man with the rats . Le Monde. 21 November 2012 . 3 September 2013 . Guilhot, Alain.
  2. Web site: Pr. Gilles-Eric Séralini Président du Conseil Scientifique Enseignant Chercheur. https://web.archive.org/web/20151222080543/http://www.criigen.org/membre/46/display/Pr-Gilles-Eric-Seralini-President-du-Conseil-Scientifique. 22 December 2015. CRIIGEN. dead.
  3. Web site: Gentechnik: "Aus nicht haltbaren Versuchen wird eine politische Kampagne". ZEIT ONLINE. 2015-12-16. Lars. Fischer . vanc .
  4. Laure Noualhat for Libération. 19 October 2012. Gilles-Eric Séralini. OGM pas du tout. Via Google Translate, English translation
  5. News: OGM : Gilles-Éric Séralini, un scientifique engagé et critiqué. Le Monde. 20 September 2012. fr.
  6. Séralini G, Moslemi S . Aromatase inhibitors: past, present and future . Molecular and Cellular Endocrinology . 178 . 1–2 . 117–31 . June 2001 . 11403901 . 10.1016/S0303-7207(01)00433-6 . 39968497 .
  7. Ces OGM qui changent le monde, Flammarion, 2010, quatrième de couverture.
  8. "HH", CRIIGEN, 12 12 November 2008 Profile, Pr Gilles Eric Séralini – President of the Scientific Board – Molecular Biology Professor
  9. News: French scientists question safety of GM corn. The Washington Post. 19 September 2012. Carman. Tim . vanc . 20 May 2013.
  10. Agence France-Presse. 19 October 2012, as posted on phys.org. Six French academies dismiss study linking GM corn to cancer (Update 2)
  11. Séralini GE, Cellier D, de Vendomois JS . New analysis of a rat feeding study with a genetically modified maize reveals signs of hepatorenal toxicity . Archives of Environmental Contamination and Toxicology . 52 . 4 . 596–602 . May 2007 . 17356802 . 10.1007/s00244-006-0149-5 . 2007ArECT..52..596S . 2521185 .
  12. Web site: GM maize MON863: French scientists doubt safety. https://web.archive.org/web/20101230200044/http://www.gmo-compass.org/eng/news/messages/200703.docu.html. 30 December 2010. GMO Compass. 16 March 2007. 11 November 2010. dead.
  13. Three Approved GMOs Linked to Organ Damage. Z Magazine. 2010. Rady. Ananda . vanc . 23. 3. https://web.archive.org/web/20131020161018/http://www.zcommunications.org/three-approved-gmos-linked-to-organ-damage-by-rady-ananda.pdf. 20 October 2013. The data 'clearly underlines adverse impacts on kidneys and liver, the dietary detoxifying organs, as well as different levels of damages to heart, adrenal glands, spleen, and haematopoietic system,' reported Gilles-Eric Séralini, a molecular biologist at Caen University.. dead.
  14. Web site: Regulatory systems for GE crops a failure: the case of MON863. 21 July 2010. Greenpeace. Greenpeace demands an immediate and complete recall of MON863 from the global market. We also call upon governments to undertake an urgent reassessment of all other authorised GE products and a strict review of current testing methods.. https://web.archive.org/web/20090330230559/http://www.greenpeace.org/raw/content/international/press/reports/gp_briefing_seralini_study.pdf. 30 March 2009. dead.
  15. Statement of the Scientific Panel on Genetically Modified Organisms on the analysis of data from a 90-day rat feeding study with MON 863 maize Web site: Statement on the analysis of data from a 90-day rat feeding study with MON 863 maize by the Scientific Panel on genetically modified organisms (GMO) . 28 June 2007 .
  16. 10.2903/j.efsa.2007.19r. EFSA review of statistical analyses conducted for the assessment of the MON 863 90-day rat feeding study. European Food Safety Authority. EFSA Journal. 2007. 5. 6. 19r. free.
  17. http://www.lefigaro.fr/sciences/20070713.WWW000000717_les_experts_europeens_innocentent_un_ogm.html Les experts européens innocentent un OGM
  18. http://www.strategie.gouv.fr/system/files/d1b51c34d01.pdf Les Organismes Génétiquement Modifiés, Annexe B. Avis de la commission du génie biomoléculaire sur l’étude statistique du CRIIGEN du maïs MON863
  19. Web site: Review of the report by Séralini et al., (2007): "New analysis of a rat feeding study with a genetically modified maize reveals signs of hepatorenal toxicity" . FSANZ final assessment report . 11 November 2010 . dead . https://web.archive.org/web/20090516043539/http://www.foodstandards.gov.au/_srcfiles/Review_of_Report_by_Seralini_et_al_July_2007.doc . 16 May 2009 .
  20. Web site: FSANZ reaffirms its risk assessment of genetically modified corn MON 863. FSANZ fact sheets 2007. 25 July 2010. 11 November 2010. dead. https://web.archive.org/web/20101216044152/http://www.foodstandards.gov.au/scienceandeducation/factsheets/factsheets2007/updatefsanzreaffirms3622.cfm. 16 December 2010.
  21. de Vendômois JS, Roullier F, Cellier D, Séralini GE . A comparison of the effects of three GM corn varieties on mammalian health . International Journal of Biological Sciences . 5 . 7 . 706–26 . December 2009 . 20011136 . 2793308 . 10.7150/ijbs.5.706 .
  22. Web site: EFSA Minutes of the 55th Plenary Meeting of the Scientific Panel on Genetically Modified Organisms Held on 27–28 January 2010 IN Parma, Italy, Annex 1, Vendemois et al 2009. European Food Safety Authority report. 11 November 2010.
  23. Web site: Opinion relating to the deposition of 15 December 2009 by the Member of Parliament, François Grosdidier, as to the conclusions of the study entitled "A comparison of the effects of three GM corn varieties on mammalian health". https://web.archive.org/web/20121030143734/http://www.food.gov.uk/multimedia/pdfs/acnfp9612a2. 30 October 2012. English translation of French High Council of Biotechnologies Scientific Committee document. 11 November 2010. dead.
  24. Web site: Feeding studies and GM corn MON863. Food Standards Australia New Zealand. July 2012. 10 October 2012. dead. https://web.archive.org/web/20121025134029/http://www.foodstandards.gov.au/scienceandeducation/factsheets/factsheets/feedingstudiesandgmc5604.cfm. 25 October 2012.
  25. 10.1186/2190-4715-23-10. Genetically modified crops safety assessments: Present limits and possible improvements. 2011. Séralini. Gilles-Eric. Mesnage. Robin. Clair. Emilie. Gress. Steeve. De Vendômois. Joël. Cellier. Dominique. Environmental Sciences Europe. 23. 10. free.
  26. News: Study linking GM maize to cancer must be taken seriously by regulators. 8 May 2013. The Guardian. London. John. Vidal . vanc . 28 September 2012.
  27. Butler D . Hyped GM maize study faces growing scrutiny . Nature . 490 . 7419 . 158 . October 2012 . 23060167 . 10.1038/490158a . 2012Natur.490..158B . free .
  28. Web site: France orders probe after rat study links genetically modified corn to cancer. Agence France-Presse. 20 September 2012. 26 December 2015.
  29. Web site: Elsevier Announces Article Retraction from Journal Food and Chemical Toxicology. Elsevier. 2013-11-29.
  30. Wallace Hayes A . Editor in Chief of Food and Chemical Toxicology answers questions on retraction . Food and Chemical Toxicology . 65 . 394–5 . March 2014 . 24407018 . 10.1016/j.fct.2014.01.006 . free .
  31. News: Cassasus. Barbara. Paper claiming GM link with tumours republished. 31 August 2015. Nature. 25 June 2014.
  32. Martinelli L, Karbarz M, Siipi H . Science, safety, and trust: the case of transgenic food . Croatian Medical Journal . 54 . 1 . 91–6 . February 2013 . 23444254 . 3584506 . 10.3325/cmj.2013.54.91 .
  33. http://www.academie-sciences.fr/pdf/rapport/avis1012.pdf Avis du 19 octobre 2012
  34. Web site: Anti-GMO Scientist Gilles-Eric Seralini, Activist Jeffrey Smith Withdraw from Food Biotech Debate . . 29 May 2013 . 4 September 2013 . Entine, Jon.
  35. Mesnage R, Defarge N, Spiroux de Vendômois J, Séralini GE . Major pesticides are more toxic to human cells than their declared active principles . BioMed Research International . 2014 . 179691 . 2014 . 24719846 . 10.1155/2014/179691 . 3955666 . free .
  36. Web site: Pesticide Study Sparks Backlash . . 10 February 2014 . 16 March 2014 . Kupferschmidt, Kai.
  37. News: GMO Opponents Are the Climate Skeptics of the Left. Slate. 2012-09-26. 2015-12-17. 1091-2339. Keith. Kloor . vanc .
  38. Web site: From Darwinius to GMOs: Journalists Should Not Let Themselves Be Played - The Loom. https://wayback.archive-it.org/all/20120921222851/http://blogs.discovermagazine.com/loom/2012/09/21/from%2Ddarwinius%2Dto%2Dgmos%2Djournalists%2Dshould%2Dnot%2Dlet%2Dthemselves%2Dbe%2Dplayed/#.VnLeP7bhCt8. dead. 21 September 2012. The Loom. 2015-12-17. 21 September 2012. Carl Zimmer.
  39. Gress S, Laurant C, Defarge N, Travert C, Séralini GÉ . Dig1 protects against locomotor and biochemical dysfunctions provoked by Roundup . BMC Complementary and Alternative Medicine . 16 . 1 . 234 . July 2016 . 27450510 . 4957837 . 10.1186/s12906-016-1226-6 . free .
  40. Book: Rational Changes in Science: Essays on Scientific Reasoning. Tuomela, R. Springer. 1987. 978-94-010-8181-8. Pitt JC, Marcello P. Boston Studies in the Philosophy of Science. 98. 83–101. Chapter 4: Science, Protoscience, and Pseudoscience. 10.1007/978-94-009-3779-6_4. Raimo Tuomela.
  41. Smith K. 2012. Homeopathy is Unscientific and Unethical. Bioethics. 26. 9. 508–12. 10.1111/j.1467-8519.2011.01956.x. 143067523. 2021-05-03. 2017-10-29. https://web.archive.org/web/20171029012949/https://zenodo.org/record/1035885. live.
  42. Book: Baran GR, Kiana MF, Samuel SP. Healthcare and Biomedical Technology in the 21st Century . Science, Pseudoscience, and Not Science: How do They Differ? . Springer. 2014. 978-1-4614-8540-7. 19–57. 10.1007/978-1-4614-8541-4_2. within the traditional medical community it is considered to be quackery.
  43. Book: Philosophy of Pseudoscience: Reconsidering the Demarcation Problem. Ladyman J. University of Chicago Press. 2013. 978-0-226-05196-3. Pigliucci M, Boudry M. 48–49. Chapter 3: Towards a Demarcation of Science from Pseudoscience. Yet homeopathy is a paradigmatic example of pseudoscience. It is neither simply bad science nor science fraud, but rather profoundly departs from scientific method and theories while being described as scientific by some of its adherents (often sincerely)..
  44. Shaw. DM. 2010. Homeopathy is where the harm is: Five unethical effects of funding unscientific 'remedies'. Journal of Medical Ethics. 36. 3. 130–31. 10.1136/jme.2009.034959. 20211989. free.
  45. News: Pharmacists urged to 'tell the truth' about homeopathic remedies. Sample I. 21 July 2008. The Guardian. London. 3 May 2021. 4 May 2021. https://web.archive.org/web/20210504155101/https://www.theguardian.com/science/2008/jul/21/pharmacists.homeophathy. live.
  46. Web site: Homeopathy. American Cancer Society. 12 October 2014. 16 March 2013. https://web.archive.org/web/20130316003948/http://www.cancer.org/treatment/treatmentsandsideeffects/complementaryandalternativemedicine/pharmacologicalandbiologicaltreatment/homeopathy. live.
  47. UK Parliamentary Committee Science and Technology Committee - "Evidence Check 2: Homeopathy"
  48. Grimes. D.R.. 2012. Proposed mechanisms for homeopathy are physically impossible. Focus on Alternative and Complementary Therapies. 17. 3. 149–55. 10.1111/j.2042-7166.2012.01162.x.
  49. Web site: Homeopathic products and practices: assessing the evidence and ensuring consistency in regulating medical claims in the EU. September 2017. European Academies' Science Advisory Council. 1. 1 October 2017. ... we agree with previous extensive evaluations concluding that there are no known diseases for which there is robust, reproducible evidence that homeopathy is effective beyond the placebo effect.. 22 September 2017. https://web.archive.org/web/20170922023958/http://www.easac.eu/fileadmin/PDF_s/reports_statements/EASAC_Homepathy_statement_web_final.pdf. live.
  50. Gasnier C, Benachour N, Clair E, Travert C, Langlois F, Laurant C, Decroix-Laporte C, Séralini GE . Dig1 protects against cell death provoked by glyphosate-based herbicides in human liver cell lines . Journal of Occupational Medicine and Toxicology . 5 . 29 . October 2010 . 20979644 . 2987375 . 10.1186/1745-6673-5-29 . free .
  51. Mesnage R, Defarge N, Rocque LM, Spiroux de Vendômois J, Séralini GE . Laboratory Rodent Diets Contain Toxic Levels of Environmental Contaminants: Implications for Regulatory Tests . PLOS ONE . 10 . 7 . e0128429 . 2015-07-02 . 26133768 . 4489719 . 10.1371/journal.pone.0128429 . 2015PLoSO..1028429M . free .
  52. Web site: Vincent . Olivier . vanc . L'Express . 19 January 2011 . OGM: deux chercheurs au tribunal . GMOs: two researchers in court . French .
  53. http://www.legifrance.gouv.fr/affichTexte.do?cidTexte=JORFTEXT000018038516&dateTexte= JORF No. 0026 du 31 janvier 2008, page 1853, texte No. 14, « décret du 30 janvier 2008 portant promotion et nomination »
  54. https://www.vdw-ev.de/wp-content/uploads/2016/07/full_reasoning_whistleblower_seralini_en.pdf
  55. Web site: Les lauréats de la Fondation Denis Guichard - Denis Guichard-Un nouveau regard sur le Vivant . 7 December 2015 . http://archive.wikiwix.com/cache/20151207233850/http://fondationdenisguichard.com/spip.php?article11 . 7 December 2015 . dead .
  56. Web site: Archived copy . 18 April 2019 . http://archive.wikiwix.com/cache/20190418043717/http://www.agriculture-environnement.fr/a-la-une,6/seralini -le-prix-de-l-ego,771.html . 18 April 2019 . dead .
  57. Web site: Gilles-Eric Séralini reconnu par ses pairs avec le prix Theo Colborn.

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