Gil McVean explained

Gil McVean
Birth Name:Gilean Alistair Tristram McVean
Nationality:British
Thesis Title:Adaptation and conflict : the differences between the sexes in mammalian genome evolution
Thesis Url:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624657
Thesis Year:1998
Doctoral Advisor:Laurence Hurst[1] [2] [3]

Gilean Alistair Tristram McVean (born February 1973)[4] is a professor of statistical genetics at the University of Oxford,[5] fellow of Linacre College, Oxford and co-founder and director of Genomics plc.[4] [6] He also co-chaired the 1000 Genomes Project analysis group.[7]

Education

From 1991-94, he completed a Bachelor of Arts degree in Biological Sciences at the University of Oxford.[8] He completed his PhD in the Department of Genetics at the University of Cambridge supervised by Laurence Hurst[9] [10] in 1998.[2] [11]

Career and research

McVean completed postdoctoral research at the University of Edinburgh from 1997 to 2000, supervised by Brian and Deborah Charlesworth.[12]

From 2000-04, he was a Royal Society University Research Fellow in the Department of Statistics at Oxford, where he has also been a University lecturer in Mathematical Genetics since 2004. He was reappointed in 2009 until retirement age.[13] In October 2006, he was appointed professor of statistical genetics at the University of Oxford.[14]

McVean's research[15] focuses on population genetics, statistics[16] and evolutionary biology including the International HapMap Project,[17] [18] recombination rates in the human genome[19] and the 1000 Genomes Project.[20] [21]

McVean developed a statistical method to look at recombination rate which helped to identify PRDM9 as a hotspot positioning gene.[22] In 2014, with Peter Donnelly, McVean co-founded Genomics plc, a genomics analysis company, as a corporate spin-off of the University of Oxford.[4] In 2017, he was a founding director of the Big Data Institute at the University of Oxford.[23]

Honours and awards

In 2006 McVean was awarded a Philip Leverhulme Prize.[24] [25]

In 2010, McVean was awarded the Francis Crick Medal and delivered that year's lecture entitled "Our genomes, our history".

In 2012, he was awarded the Weldon Memorial Prize.[26]

In 2013, he presented a talk TEDxWarwick entitled A Thousand Genomes a Thousand Stories.

In May 2014, McVean was elected as a member of the European Molecular Biology Organisation.[27]

McVean was elected Fellow of the Royal Society (FRS) in 2016[28] and a Fellow of the Academy of Medical Sciences (FMedSci).[29] [30]

Notes and References

  1. Hurst. L.. McVean. G.. A difficult phase for introns-early. Molecular evolution. Current Biology. 6. 5. 533–36. 1996. 8805261. 10.1016/S0960-9822(02)00535-3. free.
  2. PhD. University of Cambridge. Adaptation and conflict: the differences between the sexes in mammalian genome evolution. Gilean Alistair Tristram. McVean. 1998. 894602716. 15 May 2015. 11 February 2022. https://web.archive.org/web/20220211131058/https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624657. dead.
  3. Web site: https://web.archive.org/web/20150515105021/http://people.bath.ac.uk/bssldh/LaurenceDHurst/Lab_members.html. 15 May 2015. Students and post-docs past and present in the Hurst laboratory. University of Bath.
  4. Web site: Anon. 2016. Gilean MCVEAN Profile. Companies House. London. companieshouse.gov.uk. https://web.archive.org/web/20160812100701/https://beta.companieshouse.gov.uk/officers/Vk-hS4VIl5UrT2x7UrxKzWVL6Mo/appointments. 12 August 2016.
  5. Web site: McVean Group at the University of Oxford . 19 February 2009 . 29 January 2009 . https://web.archive.org/web/20090129103457/http://www.stats.ox.ac.uk/~mcvean/ . dead .
  6. Web site: Prof. Gil McVean - GENOMICS plc. 30 December 2017.
  7. Web site: Oct 10: 1000 Genomes project - Wellcome Trust Centre for Human Genetics. www.well.ox.ac.uk. 30 December 2017. https://web.archive.org/web/20180910061146/http://www.well.ox.ac.uk/oct-10-1000-genomes-project. 10 September 2018. dead.
  8. Gil McVean's
  9. McVean. G.T.. Hurst. L.D.. 10.1038/386388a0. Evidence for a selectively favourable reduction in the mutation rate of the X chromosome. Nature. 386. 6623. 388–92. 1997. 9121553. 1997Natur.386..388M. 4343123.
  10. Hurst. L.D.. McVean. G.T.. 10.1038/381650a0. ...And scandalous symbionts. Nature. 381. 6584. 650–51. 1996. 8649507. 1996Natur.381..650H. free.
  11. Web site: Gilean McVean profile. Oxford University . dead. https://web.archive.org/web/20171024154711/http://www.stats.ox.ac.uk/people/academic_staff/gilean_mcvean. 24 October 2017. 30 December 2017.
  12. Charlesworth. D.. Charlesworth. B.. McVean. G.. Genome sequences and evolutionary biology, a two-way interaction. Trends in Ecology & Evolution. 16. 5. 235–42. 2001. 11301152. 10.1016/S0169-5347(01)02126-7.
  13. Web site: Oxford University Gazette - Reappointments. 14 May 2009. ox.ac.uk. 30 December 2017. dead. https://web.archive.org/web/20090530021651/https://www.ox.ac.uk/gazette/2008-9/weekly/140509/exam.htm. 30 May 2009.
  14. Web site: Oxford University Gazette. ox.ac.uk. 12 July 2016. dead. https://web.archive.org/web/20131002062544/http://www.ox.ac.uk/gazette/2006-7/supps/1_4784.htm. 2 October 2013.
  15. https://scholar.google.com/scholar?q=gilean+mcvean Gilean McVean profile
  16. Reshef . D. N. . Reshef . Y. A. . Finucane . H. K. . Grossman . S. R. . McVean . G. . Gilean McVean. Turnbaugh . P. J. . Lander . E. S. . Eric Lander. Mitzenmacher . M. . Sabeti . P. C. . Pardis Sabeti. 10.1126/science.1205438 . Detecting Novel Associations in Large Data Sets . Science . 334 . 6062 . 1518–1524 . 2011 . 22174245. 3325791 . 2011Sci...334.1518R .
  17. Frazer . K. A. . Frazer . D. G. . Ballinger . D. R. . Cox . D. A. . Hinds . L. L. . Stuve . R. A. . Gibbs . J. W. . Belmont . A. . Boudreau . P. . Hardenbol . 10.1038/nature06258 . S. M. . Leal . S. . Pasternak . D. A. . Wheeler . T. D. . Willis . F. . Yu . H. . Yang . C. . Zeng . Y. . Gao . H. . Hu . W. . Hu . C. . Li . W. . Lin . S. . Liu . H. . Pan . X. . Tang . J. . Wang . W. . Wang . J. . Yu . B. . Zhang . Q. . Zhang . H. . A second generation human haplotype map of over 3.1 million SNPs . Nature . 449 . 7164 . 851–61 . 2007 . 17943122 . 2689609 . 2007Natur.449..851F . 29 .
  18. Sabeti . Pardis C.. Pardis Sabeti . Varilly . Patrick . Fry . Ben . Lohmueller . Jason . Hostetter . Elizabeth . Cotsapas . Chris . Xie . Xiaohui . Byrne . Elizabeth H. . McCarroll . Steven A. . Gaudet . Rachelle . Schaffner . Stephen F. . Lander . Eric S.. The International HapMap Consortium . Frazer . Kelly A. . Ballinger . Dennis G. . Cox . David R. . Hinds . David A. . Stuve . Laura L. . Gibbs . Richard A. . Belmont . John W. . Boudreau . Andrew . Hardenbol . Paul . Leal . Suzanne M. . Pasternak . Shiran . Wheeler . David A. . Willis . Thomas D. . Yu . Fuli . Yang . Huanming . Zeng . Changqing Zeng . Gao . Yang . Genome-wide detection and characterization of positive selection in human populations . Nature . 449 . 7164 . 913–918 . 2007 . 17943131 . 2687721 . 10.1038/nature06250 . 2007Natur.449..913S. 29.
  19. McVean . G. A. T. . Myers . S. . Hunt . S. . Deloukas . P. . Bentley . D. . Donnelly . P. . The Fine-Scale Structure of Recombination Rate Variation in the Human Genome . 10.1126/science.1092500 . Science . 304 . 5670 . 581–584 . 2004 . 15105499 . 2004Sci...304..581M . 20616898 .
  20. Danecek . P. . Auton . A. . Abecasis . G. . Albers . C. A. . Banks . E. . Depristo . M. A. . Handsaker . R. . Lunter . G. . Marth . G. . Sherry . S. T. . McVean . G. . Durbin . R. . 1000 Genomes Project Analysis Group . The Variant Call Format and VCFtools . 10.1093/bioinformatics/btr330 . Bioinformatics . 2011 . 21653522 . 3137218. 27 . 15 . 2156–58.
  21. Hernandez . R. D. . Kelley . J. L. . Elyashiv . E. . Melton . S. C. . Auton . A. . McVean . G. . 1000 Genomes Project . . Sella . G. . Przeworski . M. . 10.1126/science.1198878 . Classic Selective Sweeps Were Rare in Recent Human Evolution . Science . 331 . 6019 . 920–24 . 2011 . 21330547 . 3669691 . 2011Sci...331..920H .
  22. Web site: Gilean McVean. royalsociety.org. 30 December 2017.
  23. Web site: Professor Cecilia Lindgren appointed Director of the Big Data Institute — Oxford Big Data Institute . www.bdi.ox.ac.uk . 29 April 2021.
  24. Web site: AWARDS MADE IN 2006. 2006. leverhulme.ac.uk. The Leverhulme Trust. 30 December 2017. https://web.archive.org/web/20160810103012/https://www.leverhulme.ac.uk/sites/default/files/imported_pdfs/2006.pdf. 10 August 2016. dead.
  25. Web site: Philip Leverhulme Prizes 2006. 2006. leverhulme.ac.uk. The Leverhulme Trust. 30 December 2017.
  26. Web site: Professor Gil McVean awarded the Weldon Memorial Prize 2012 - Wellcome Trust Centre for Human Genetics. well.ox.ac.uk. 30 December 2017.
  27. Web site: EMBO enlarges its membership for 50th anniversary. embo.org. 30 December 2017.
  28. Web site: Gilean McVean. Royal Society. London. royalsociety.org. Anon. 2016. https://web.archive.org/web/20160429121403/https://royalsociety.org/people/gilean-mcvean-12885. 29 April 2016.
  29. Web site: New Fellows: Academy of Medical Sciences. acmedsci.ac.uk. 30 December 2017.
  30. Web site: Professor Gil McVean elected a Fellow of the Royal Society - GENOMICS plc. 30 December 2017.

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