| Birth Date: | 16 September 1920 |
| Birth Place: | Florence, Italy |
| Death Place: | Florence, Italy |
| Sport: | Water polo |
Gianfranco Pandolfini (16 September 1920 - 3 January 1997) was an Italian water polo player who competed in the 1948 Summer Olympics.
Pandolfini was part of the Italian team which won the gold medal. He played five matches.
His older brother Tullio was also a member of the team and played two matches.