| Type: | Cardinal |
| Giacomo Cavalieri | |
| See: | Datary of His Holiness |
| Cardinal priest of Sant'Eusebio | |
| Enthroned: | 15 September 1623 – 28 January 1629 |
| Cardinal: | 19 January 1626 |
| Birth Date: | 1565 |
| Birth Place: | Rome, Italy |
| Death Date: | 28 January 1629 |
| Death Place: | Tivoli, Italy |
Giacomo Cavalieri (Rome, 1565 - Tivoli, 28 January 1629) was born in Rome in 1565 to Giacomo Cavalieri and Diana Santori, related to the Borghese and Paluzzi Albertoni families. He became referendary of the Tribunal of the Apostolic Signature in the Roman Curia and governor of Faenza and Città di Castello and auditor of the Roman Rota. On 15 September 1623 he was appointed datary of His Holiness.
Pope Urban VIII created him cardinal priest in the consistory of 19 January 1626. He opted for the title of Sant'Eusebio on 9 February 1626. He died on 28 January 1629 in Tivoli.