| Honorific-Prefix: | Most Reverend |
| Giacomo Antonio Leofanti | |
| Bishop of Patti | |
| Church: | Catholic Church |
| Diocese: | Diocese of Patti |
| Term: | 1486–1494 |
| Predecessor: | Giacomo di Santa Lucia |
| Successor: | Giovanni Marquet |
| Death Date: | 1494 |
| Death Place: | Patti, Italy |
Giacomo Antonio Leofanti (died 1494) was a Roman Catholic prelate who served as Bishop of Patti (1486–1494).[1]
On 9 February 1486, he was appointed by Pope Innocent VIII as Bishop of Patti. He served as Bishop of Patti until his death in 1494.