| George Ghica | |
| Succession: | Prince of Moldavia |
| Reign1: | 3 March 1658 – 2 November 1659 |
| Predecessor1: | Gheorghe Ștefan |
| Successor1: | Constantin Șerban |
| Succession2: | Prince of Wallachia |
| Reign2: | 20 November 1659 – 1 November 1660 |
| Predecessor2: | Mihnea III |
| Successor2: | Grigore I Ghica |
| Spouse: | Smaragda (Smada) Lâna |
| Issue: | Grigore I Ghica |
| House: | Ghica |
| House-Type: | Dynasty |
| Father: | Matei Ghica |
| Birth Date: | 3 March 1600 |
| Birth Place: | Köprülü, Rumelia Eyalet, Ottoman Empire |
| Death Date: | 2 November 1664 |
| Death Place: | Istanbul |
| Signature: | George Ghica's signature, 1659.svg |
| Religion: | Orthodox |
George Ghica (Albanian: Gjergj Gjika, Romanian; Moldavian; Moldovan: Gheorghe Ghica) (3 March 1600 - 2 November 1664) founder of the Ghica family, was Prince of Moldavia in 1658–1659 and Prince of Wallachia in 1659–1660.
While in Istanbul, he became close friends with the Grand Vizier Köprülü Mehmed Pasha and helped him on to high positions. As Prince of Wallachia he moved the capital from Târgoviște to Bucharest.
From him are descended the numerous branches of the family which became notable in the history of Moldavia and Wallachia. His son was Grigore I Ghica.