| Date: | 27 April 1960 |
| Country: | Union of African States |
| Flag Year: | 1958 |
| Yes: | 1008740 |
| No: | 131425 |
| Electorate: | 2098651 |
A constitutional referendum was held in Ghana on 27 April 1960. The main issue was a change in the country's status from a constitutional monarchy with Elizabeth II as head of state, to a republic with a presidential system of government.
Presidential elections were held alongside the referendum, which were won by the incumbent Prime Minister, Kwame Nkrumah. He was inaugurated on 1 July 1960, replacing Queen Elizabeth II as head of state, and thus eliminating the post of Governor-General.
Four years later another referendum strengthened the president's powers and turned the country into a one-party state (with an official result of 99.91% in support).