| Gertrudis Echenique | |
| Office: | First Lady of Chile |
| Term Label: | In role |
| Term Start: | September 18, 1896 |
| Term End: | July 12, 1901 |
| President: | Federico Errázuriz Echaurren |
| Predecessor: | Leonor Frederick Ledesma |
| Successor: | María Errázuriz Echaurren |
| Birth Name: | Gertrudis Josefa del Carmen Echenique y Mujica |
| Birth Place: | Santiago, Chile |
| Spouse: | Federico Errázuriz Echaurren |
| Children: | Federico Elena |
| Parents: | Juan José Echenique Bascuñán Jesús Mujica Echaurren |
Gertrudis Josefa del Carmen Echenique y Mujica (1849–1928) was First Lady of Chile between 1896 and 1901.
She was born in Santiago, the daughter of Juan José Echenique Bascuñán and of his second wife, Jesús Mujica Echaurren. She married Federico Errázuriz Echaurren in 1868, and together they had two children: Federico (1869-1897) and Elena Errázuriz Echeñique (1870-1966). After the death of her husband, she withdrew to her hacienda of El Huique, in the province of Colchagua, which she continued to manage until her death.