Geroprotector Explained

A geroprotector aims to affect the root cause of aging and age-related diseases, and thus prolong the life span of animals.[1] [2] Some possible geroprotectors include melatonin,[3] carnosine,[4] metformin,[5] rapamycin,[6] nicotinamide mononucleotide (NMN)[7] and delta sleep-inducing peptide.[8]

Geroprotectors could belong to multiple classes depending on which of the hallmarks of aging they influence.

The distinction between geroprotectors and senotherapeutics is an evolving area of aging research. Geroprotectors broadly aim to target multiple mechanisms of aging, prolonging lifespan and healthspan by addressing the fundamental causes of aging. Senotherapeutics, on the other hand, are a subset of therapies that specifically target senescent cells, which are dysfunctional cells that accumulate with age and contribute to inflammation and age-related diseases.[9]

See also

External links

Notes and References

  1. Alexey Moskalev, Elizaveta Chernyagina, Anna Kudryavtseva & Mikhail Shaposhnikov . Geroprotectors: A Unified Concept and Screening Approaches . Aging and Disease . 8 . 3 . 354–363 . 2017 . 10.14336/AD.2016.1022 . 28580190 . 5440114.
  2. . Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease . . 7 . 9 . 616–628 . 2015 . 10.18632/aging.100799 . 26342919 . 4600621.
  3. 16678784 . 2006 . Anisimov . VN . Popovich . IG . Zabezhinski . MA . Anisimov . SV . Vesnushkin . GM . Vinogradova . IA . Melatonin as antioxidant, geroprotector and anticarcinogen . Biochimica et Biophysica Acta (BBA) - Bioenergetics . 1757 . 5–6 . 573–89 . 10.1016/j.bbabio.2006.03.012 . free .
  4. 20017611 . 2010 . Boldyrev . AA . Stvolinsky . SL . Fedorova . TN . Suslina . ZA . Carnosine as a natural antioxidant and geroprotector: From molecular mechanisms to clinical trials . 13 . 2–3 . 156–8 . 10.1089/rej.2009.0923 . Rejuvenation Research.
  5. 21882902 . 2011 . Bulterijs . S . 40645408 . Metformin As a Geroprotector . 10.1089/rej.2011.1153 . Rejuvenation Research . 14 . 5 . 469–82.
  6. Dumas . Sabrina N . Lamming . Dudley W . 2020-01-01 . Next Generation Strategies for Geroprotection via mTORC1 Inhibition . The Journals of Gerontology: Series A . 75 . 1 . 14–23 . 10.1093/gerona/glz056 . 1079-5006 . 6909887 . 30794726.
  7. https://www.cell.com/cell-metabolism/pdf/S1550-4131(16)30495-8.pdf Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice
  8. 21809625 . 2011 . Bondarenko . TI . Mechanism of delta-sleep inducing peptide geroprotective activity . Adv Gerontol . 24 . 1 . 80–92.
  9. Al-Naggar . Iman M. A. . 24 October 2020 . Senolytics: Targeting Senescent Cells for Age-Associated Diseases . Current Molecular Biology Reports . 6 . 161–172 . Springer.

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