Geraniol 8-hydroxylase explained

Geraniol 8-hydroxylase
Ec Number:	1.14.14.83

Geraniol 8-hydroxylase (Formerly, CYP76B6, G10H, CrG10H, SmG10H) is an enzyme with systematic name geraniol,NADPH:oxygen oxidoreductase (8-hydroxylating).^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

geraniol + NADPH + H⁺ + O₂

\rightleftharpoons (6E)-8-hydroxygeraniol + NADP⁺ + H₂O

Geraniol 8-hydroxylase is a cytochrome P450 and therefore requires a partner cytochrome P450 reductase for functional expression.

Notes and References

1. Collu G, Unver N, Peltenburg-Looman AM, van der Heijden R, Verpoorte R, Memelink J . Geraniol 10-hydroxylase, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis . FEBS Letters . 508 . 2 . 215–20 . November 2001 . 11718718 . 10.1016/s0014-5793(01)03045-9 . 45615763 . free .
2. Wang J, Liu Y, Cai Y, Zhang F, Xia G, Xiang F . Cloning and functional analysis of geraniol 10-hydroxylase, a cytochrome P450 from Swertia mussotii Franch . Bioscience, Biotechnology, and Biochemistry . 74 . 8 . 1583–90 . 2010 . 20699579 . 10.1271/bbb.100175 . 26540510 .
3. Sung PH, Huang FC, Do YY, Huang PL . Functional expression of geraniol 10-hydroxylase reveals its dual function in the biosynthesis of terpenoid and phenylpropanoid . Journal of Agricultural and Food Chemistry . 59 . 9 . 4637–43 . May 2011 . 21504162 . 10.1021/jf200259n .