| State: | GA |
| Type: | SR |
| Route: | 281 |
| Map Custom: | yes |
| Map Notes: | SR 281 highlighted in red |
| Alternate Name: | Wildcat Bridge Road |
| Length Mi: | 11.9 |
| Direction A: | South |
| Direction B: | North |
| Terminus A: | northeast of Danielsville |
| Junction: | northeast of Danielsville |
| Terminus B: | in Royston |
| Counties: | Madison, Franklin, Hart |
| Previous Type: | SR |
| Previous Route: | 280 |
| Next Type: | SR |
| Next Route: | 282 |
State Route 281 (SR 281) is a south–north state highway located in the northeastern part of the U.S. state of Georgia. Its route is in Madison and Franklin Counties, with a brief section straddling the Madison-Hart County line.
SR 281 begins at an intersection with US 29/SR 8 (General Daniels Avenue North) northeast of Danielsville. It heads northeast to an intersection with SR 191 (Dalton Drive). The highway crosses the Broad River, and curves into a more north-northeast routing. It passes through rural parts of Madison County and runs along the Madison-Hart County line before entering Franklin County. Almost immediately after crossing the county line, SR 281 meets its northern terminus, an intersection with SR 17 Business (Church Street) in Royston.