| State: | GA |
| Type: | SR |
| Route: | 159 |
| Alternate Name: | North Railroad Street, North Street |
| Map Custom: | yes |
| Map Notes: | SR 159 highlighted in red |
| Length Mi: | 18.9 |
| Direction B: | South |
| Terminus B: | in Ashburn |
| Junction: | in Ashburn |
| Direction A: | North |
| Terminus A: | in Pitts |
| Counties: | Turner, Wilcox |
| Previous Type: | SR |
| Previous Route: | 158 |
| Next Type: | SR |
| Next Route: | 162 |
State Route 159 (SR 159) is a south–north state highway in the south-central part of the U.S. state of Georgia. Its routing is in portions of Turner and Wilcox counties.
SR 164 begins at an intersection with US 41/SR 7 in Ashburn It has an interchange with Interstate 75 (I-75) just before leaving town. It heads northeast until it meets a concurrency with SR 90. It heads north to the town of Pitts, where it meets its northern terminus, an intersection with US 280/SR 30.